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1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats

Sato, Tsunehisa ; Mimuro, Soichiro ; Katoh, Takasumi ; Kurita, Tadayoshi ; Truong, Sang Kien ; Kobayashi, Kensuke ; Makino, Hiroshi ; Doi, Matsuyuki ; Nakajima, Yoshiki

Journal of anesthesia, 2020-04, Vol.34 (2), p.268-275 [Periódico revisado por pares]

Singapore: Springer Singapore

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  • Título:
    1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats
  • Autor: Sato, Tsunehisa ; Mimuro, Soichiro ; Katoh, Takasumi ; Kurita, Tadayoshi ; Truong, Sang Kien ; Kobayashi, Kensuke ; Makino, Hiroshi ; Doi, Matsuyuki ; Nakajima, Yoshiki
  • Assuntos: Anesthesiology ; Animals ; Critical Care Medicine ; Disease Models, Animal ; Emergency Medicine ; Endothelium ; Glycocalyx ; Hemoglobin ; Hemorrhagic shock ; Hydrogen ; Intensive ; Medicine ; Medicine & Public Health ; Original Article ; Pain Medicine ; Prospective Studies ; Rats ; Rats, Sprague-Dawley ; Resuscitation ; Shock, Hemorrhagic
  • É parte de: Journal of anesthesia, 2020-04, Vol.34 (2), p.268-275
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Purpose Hydrogen gas (H 2 ) inhalation improved the survival rate of hemorrhagic shock. However, its mechanisms are unknown. We hypothesized that H 2 protected the endothelial glycocalyx during hemorrhagic shock and prolonged survival time. Methods 83 Sprague–Dawley rats were anesthetized with isoflurane. The animals were randomly assigned to 5 groups: room air with no shock, 1.2% H 2 with no shock, room air with shock (Control-S), 1.2% H 2 with shock (H 2 1.2%-S), and 3.0% H 2 with shock (H 2 3.0%-S). Shock groups were bled to a mean arterial pressure of 30–35 mmHg and held for 60 min, then resuscitated with normal saline at fourfold the amount of the shed blood volume. Results The syndecan-1 level was significantly lower in the H 2 1.2%-S [8.3 ± 6.6 ng/ml; P  = 0.01; 95% confidence interval (CI), 3.2–35.8] than in the Control-S (27.9 ± 17.0 ng/ml). The endothelial glycocalyx was significantly thicker in the H 2 1.2%-S (0.15 ± 0.02 µm; P  = 0.007; 95% CI, 0.02–0.2) than in the Control-S (0.06 ± 0.02 µm). The survival time was longer in the H 2 1.2%-S (327 ± 67 min, P  = 0.0160) than in the Control-S (246 ± 69 min). The hemoglobin level was significantly lower in the H 2 1.2%-S (9.4 ± 0.5 g/dl; P = 0.0034; 95% CI, 0.6–2.9) than in the Control-S (11.1 ± 0.8 g/dl). However, the H 2 3.0%-S was not significant. Conclusions Inhalation of 1.2% H 2 gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock. Therapeutic efficacy might vary depending on the concentration.
  • Editor: Singapore: Springer Singapore
  • Idioma: Inglês
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