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A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo

Delebinski, Catharina I ; Twardziok, Monika ; Kleinsimon, Susann ; Hoff, Florian ; Mulsow, Katharina ; Rolff, Jana ; Jäger, Sebastian ; Eggert, Angelika ; Seifert, Georg Pandey, Siyaram

PloS one, 2015-08, Vol.10 (8), p.e0133892-e0133892 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo
Autor: Delebinski, Catharina I ; Twardziok, Monika ; Kleinsimon, Susann ; Hoff, Florian ; Mulsow, Katharina ; Rolff, Jana ; Jäger, Sebastian ; Eggert, Angelika ; Seifert, Georg
Pandey, Siyaram
Assuntos: Acids ; Acute myelocytic leukemia ; Acute myeloid leukemia ; Adolescent ; Animals ; Anticancer properties ; Antineoplastic Combined Chemotherapy Protocols - chemistry ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Bcl-2 protein ; Cancer ; Cancer therapies ; Care and treatment ; Caspase ; Caspase-8 ; Cell proliferation ; Cell Proliferation - drug effects ; Child ; Cyclodextrin ; Cyclodextrins ; Cytarabine ; Dose-Response Relationship, Drug ; Female ; Health aspects ; HL-60 Cells ; Humans ; Hydrophobicity ; Hypericum perforatum ; Interleukin Receptor Common gamma Subunit - deficiency ; Interleukin Receptor Common gamma Subunit - genetics ; Kinases ; Lectins ; Leukemia ; Leukemia, Myeloid, Acute - drug therapy ; Leukemia, Myeloid, Acute - pathology ; Male ; Materia medica, Vegetable ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Mistletoe ; Mistletoes ; Oleanolic acid ; Oleanolic Acid - administration & dosage ; Oleanolic Acid - pharmacology ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Lectins - administration & dosage ; Plant Lectins - pharmacology ; Proteins ; Solubility ; Terpenes ; Triterpenes ; Triterpenes - administration & dosage ; Triterpenes - pharmacology ; Tumor Burden - drug effects ; Tumor Cells, Cultured ; Tumors ; U937 Cells ; Viscum album ; Viscum album - chemistry ; Weight reduction ; Xenograft Model Antitumor Assays
É parte de: PloS one, 2015-08, Vol.10 (8), p.e0133892-e0133892
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: GS CD. Performed the experiments: CD MT SK FH KM JR SJ. Analyzed the data: CD MT AE GS. Contributed reagents/materials/analysis tools: SJ KM. Wrote the paper: CD MT SK SJ GS.
Competing Interests: The authors have the following interests. Jana Rolff is employed by EPO GmbH and Sebastian Jäger by Birken AG. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Descrição: Aqueous Viscum album L. extracts are widely used in complementary cancer medicine. Hydrophobic triterpene acids also possess anti-cancer properties, but due to their low solubility they do not occur in significant amounts in aqueous extracts. Using cyclodextrins we solubilised mistletoe triterpenes (mainly oleanolic acid) and investigated the effect of a mistletoe whole plant extract on human acute myeloid leukaemia cells in vitro, ex vivo and in vivo. Single Viscum album L. extracts containing only solubilised triterpene acids (TT) or lectins (viscum) inhibited cell proliferation and induced apoptosis in a dose-dependent manner in vitro and ex vivo. The combination of viscum and TT extracts (viscumTT) enhanced the induction of apoptosis synergistically. The experiments demonstrated that all three extracts are able to induce apoptosis via caspase-8 and -9 dependent pathways with down-regulation of members of the inhibitor of apoptosis and Bcl-2 families of proteins. Finally, the acute myeloid leukaemia mouse model experiment confirmed the therapeutic effectiveness of viscumTT-treatment resulting in significant tumour weight reduction, comparable to the effect in cytarabine-treated mice. These results suggest that the combination viscumTT may have a potential therapeutic value for the treatment AML.
Editor: United States: Public Library of Science
Idioma: Inglês

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A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo

Delebinski, Catharina I ; Twardziok, Monika ; Kleinsimon, Susann ; Hoff, Florian ; Mulsow, Katharina ; Rolff, Jana ; Jäger, Sebastian ; Eggert, Angelika ; Seifert, Georg Pandey, Siyaram

United States: Public Library of Science

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