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Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes
Siddiqi, Khwaja Salahuddin ; ur Rahman, Aziz ; Tajuddin ; Husen, Azamal
Nanoscale research letters, 2018-05, Vol.13 (1), p.141-13, Article 141
[Peer Reviewed Journal]
New York: Springer US
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Title:
Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes
Author:
Siddiqi, Khwaja Salahuddin
;
ur Rahman, Aziz
;
Tajuddin
;
Husen, Azamal
Subjects:
Antimicrobial
;
Apoptosis
;
Biocompatibility
;
Biodistribution
;
Biomolecules
;
Cell death
;
Cell membranes
;
Cell walls
;
Chemistry and Materials Science
;
Cytoplasm
;
E coli
;
Klebsiella
;
Materials Science
;
Mechanism
;
Microcrystals
;
Microorganisms
;
Molecular Medicine
;
Morphology
;
Nano Review
;
Nanochemistry
;
Nanoparticles
;
Nanoscale Science and Technology
;
Nanotechnology
;
Nanotechnology and Microengineering
;
Pseudomonas aeruginosa
;
Sarcina
;
Sun screens
;
Toxicity
;
Zinc oxide
;
Zinc oxide nanoparticles
;
Zinc oxides
Is Part Of:
Nanoscale research letters, 2018-05, Vol.13 (1), p.141-13, Article 141
Notes:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Description:
Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. Its microcrystals are very efficient light absorbers in the UVA and UVB region of spectra due to wide bandgap. Impact of zinc oxide on biological functions depends on its morphology, particle size, exposure time, concentration, pH, and biocompatibility. They are more effective against microorganisms such as Bacillus subtilis , Bacillus megaterium , Staphylococcus aureus , Sarcina lutea , Escherichia coli , Pseudomonas aeruginosa , Klebsiella pneumonia , Pseudomonas vulgaris , Candida albicans , and Aspergillus niger . Mechanism of action has been ascribed to the activation of zinc oxide nanoparticles by light, which penetrate the bacterial cell wall via diffusion. It has been confirmed from SEM and TEM images of the bacterial cells that zinc oxide nanoparticles disintegrate the cell membrane and accumulate in the cytoplasm where they interact with biomolecules causing cell apoptosis leading to cell death.
Publisher:
New York: Springer US
Language:
English
Links
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