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Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, Shaden A M ; Elias, Nizar ; Farag, Mohamed A ; Chen, Lei ; Saeed, Aamer ; Hegazy, Mohamed-Elamir F ; Moustafa, Moustafa S ; Abd El-Wahed, Aida ; Al-Mousawi, Saleh M ; Musharraf, Syed G ; Chang, Fang-Rong ; Iwasaki, Arihiro ; Suenaga, Kiyotake ; Alajlani, Muaaz ; Göransson, Ulf ; El-Seedi, Hesham R

Marine drugs, 2019-08, Vol.17 (9), p.491 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Marine Natural Products: A Source of Novel Anticancer Drugs
Autor: Khalifa, Shaden A M ; Elias, Nizar ; Farag, Mohamed A ; Chen, Lei ; Saeed, Aamer ; Hegazy, Mohamed-Elamir F ; Moustafa, Moustafa S ; Abd El-Wahed, Aida ; Al-Mousawi, Saleh M ; Musharraf, Syed G ; Chang, Fang-Rong ; Iwasaki, Arihiro ; Suenaga, Kiyotake ; Alajlani, Muaaz ; Göransson, Ulf ; El-Seedi, Hesham R
Assuntos: Actinomycetes ; Algae ; Animals ; anticancer ; Anticancer properties ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antitumor ; Antitumor agents ; Apoptosis ; Aquatic Organisms - chemistry ; Aquatic plants ; Bioactive compounds ; Biodiversity ; Biological effects ; Biological Products - isolation & purification ; Biological Products - pharmacology ; Biological Products - therapeutic use ; Breast cancer ; Cancer ; Cancer therapies ; Chemicophysical properties ; Chemotherapy ; Clinical trials ; Clinical Trials as Topic ; Corals ; cytotoxic ; Disease Models, Animal ; Drugs ; Fungi ; Humans ; In vivo methods and tests ; Leukemia ; marine ; Marine chemistry ; Marine organisms ; Marine plants ; Metabolites ; microorganism ; Molecular modelling ; Natural products ; Neoplasms ; Neoplasms - drug therapy ; NMR ; Nuclear magnetic resonance ; Organisms ; plants ; Review ; Signal transduction ; Testicular cancer ; Treatment Outcome ; Womens health
É parte de: Marine drugs, 2019-08, Vol.17 (9), p.491
Notas: ObjectType-Article-2
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ObjectType-Review-1
Descrição: Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Marine Natural Products: A Source of Novel Anticancer Drugs

Switzerland: MDPI AG

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