skip to main content
Idioma:

Limits to sustained energy intake. XXX. Constraint or restraint? Manipulations of food supply show peak food intake in lactation is constrained

Zhao, Zhi-Jun ; Derous, Davina ; Gerrard, Abby ; Wen, Jing ; Liu, Xue ; Tan, Song ; Hambly, Catherine ; Speakman, John R

Journal of experimental biology, 2020-04, Vol.223 (Pt 8) [Periódico revisado por pares]

England

Texto completo disponível

Citações Citado por
  • Título:
    Limits to sustained energy intake. XXX. Constraint or restraint? Manipulations of food supply show peak food intake in lactation is constrained
  • Autor: Zhao, Zhi-Jun ; Derous, Davina ; Gerrard, Abby ; Wen, Jing ; Liu, Xue ; Tan, Song ; Hambly, Catherine ; Speakman, John R
  • É parte de: Journal of experimental biology, 2020-04, Vol.223 (Pt 8)
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Lactating mice increase food intake 4- to 5-fold, reaching an asymptote in late lactation. A key question is whether this asymptote reflects a physiological constraint, or a maternal investment strategy (a 'restraint'). We exposed lactating mice to periods of food restriction, hypothesizing that if the limit reflected restraint, they would compensate by breaching the asymptote when refeeding. In contrast, if it was a constraint, they would by definition be unable to increase their intake on refeeding days. Using isotope methods, we found that during food restriction, the females shut down milk production, impacting offspring growth. During refeeding, food intake and milk production rose again, but not significantly above unrestricted controls. These data provide strong evidence that asymptotic intake in lactation reflects a physiological/physical constraint, rather than restraint. Because hypothalamic neuropeptide Y ( ) was upregulated under both states of restriction, this suggests the constraint is not imposed by limits in the capacity to upregulate hunger signalling (the saturated neural capacity hypothesis). Understanding the genetic basis of the constraint will be a key future goal and will provide us additional information on the nature of the constraining factors on reproductive output, and their potential links to life history strategies.
  • Editor: England
  • Idioma: Inglês
Links
Voltar para lista de resultados
Resultado  1 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.