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Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation

Chen, Zheng ; Qi, Tao ; Qin, Xiao-ping ; Wang, Jue ; Huang, Zhang-sen ; Hu, Xiao-yong ; Chen, Guo ; Qu, Li-jun ; Zhuo, Yu-min Xu, Zhenbo ; Zhenbo Xu

BioMed research international, 2020, Vol.2020, p.8812923-11 [Periódico revisado por pares]

United States: Hindawi

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Título:
Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation
Autor: Chen, Zheng ; Qi, Tao ; Qin, Xiao-ping ; Wang, Jue ; Huang, Zhang-sen ; Hu, Xiao-yong ; Chen, Guo ; Qu, Li-jun ; Zhuo, Yu-min
Xu, Zhenbo ; Zhenbo Xu
Assuntos: Aged ; Aged, 80 and over ; AKT protein ; Antibodies ; Apoptosis ; Apoptosis - genetics ; Biomarkers ; Cancer therapies ; Carcinogenesis ; Cell culture ; Cell cycle ; Cell Cycle - genetics ; Cell growth ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - genetics ; Disease Progression ; Epigenetics ; Flow cytometry ; Gene Knockdown Techniques ; Humans ; In vivo methods and tests ; Male ; Metastasis ; Middle Aged ; Neoplasm Invasiveness - genetics ; Nucleoli ; Pathogenesis ; Patients ; Plasmids ; Prostate ; Prostate - chemistry ; Prostate - pathology ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Proteins ; Proto-Oncogene Proteins c-akt - genetics ; Proto-Oncogene Proteins c-akt - metabolism ; Ribonucleic acid ; RNA ; RNA polymerase ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Secretion ; snoRNA ; Tumorigenesis ; Tumors ; Vascular endothelial growth factor
É parte de: BioMed research international, 2020, Vol.2020, p.8812923-11
Notas: Academic Editor: Zhenbo Xu
Descrição: The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected from 85 patients. Then, colony formation assays, MTT experiments, and flow cytometry were used to examine the effect of SNHG12 on proliferation, cell cycle distribution, and apoptosis of DU145 cells. Further, Transwell invasion assay was utilized to assess whether SNHG12 participates in PCa cell invasion and affects the secretion of VEGF secretion in DU145 cells. Finally, we investigated the effect of SNHG12 on tumor growth in vivo. We found that SNHG12 promoted cell proliferation and suppressed apoptosis in PCa cells, which suggests that SNHG12 is probably a novel PCa biomarker and therapy target of PCa.
Editor: United States: Hindawi
Idioma: Inglês

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Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation

Chen, Zheng ; Qi, Tao ; Qin, Xiao-ping ; Wang, Jue ; Huang, Zhang-sen ; Hu, Xiao-yong ; Chen, Guo ; Qu, Li-jun ; Zhuo, Yu-min Xu, Zhenbo ; Zhenbo Xu

United States: Hindawi

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