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Effects of an Inorganic Ca2+-Channel Blocker (Lanthanum) on Experimental Atherosclerosis in Rabbits

NAITO, Michitaka ; ASAI, Kan-ichi ; SHIBATA, Kazuaki ; MIURA, Satoru ; ENDO, Hidetoshi ; HAYAKAWA, Michihiko ; IWATA, Yoshio ; SHIMOKATA, Hiroshi ; FUJITA, Katsunaru ; USHIGOME, Yasuyo ; YOSHIMINE, Noboru ; KUZUYA, Fumio

The Journal of Japan Atherosclerosis Society, 1983/12/01, Vol.11(5), pp.997-1004

Japan Atherosclerosis Society

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  • Título:
    Effects of an Inorganic Ca2+-Channel Blocker (Lanthanum) on Experimental Atherosclerosis in Rabbits
  • Autor: NAITO, Michitaka ; ASAI, Kan-ichi ; SHIBATA, Kazuaki ; MIURA, Satoru ; ENDO, Hidetoshi ; HAYAKAWA, Michihiko ; IWATA, Yoshio ; SHIMOKATA, Hiroshi ; FUJITA, Katsunaru ; USHIGOME, Yasuyo ; YOSHIMINE, Noboru ; KUZUYA, Fumio
  • Assuntos: Ca2+-channel blocker ; experimental atherosclerosis ; hypercholesterolemia ; lanthanum
  • É parte de: The Journal of Japan Atherosclerosis Society, 1983/12/01, Vol.11(5), pp.997-1004
  • Descrição: We observed the effects of lanthanum (La3+, an inorganic Ca2+-channel blocker) on experimental atherosclerosis in rabbits fed on cholesterol. 16 male Japanese white rabbits weighing 2.1-2.7kg were fed on a 1% cholesterol diet for two weeks, and then divided into two groups so as not to make statistical differences of the serum total cholesterol levels between the two groups. One group was fed on a 1% cholesterol diet plus 0.12% LaCl3 (40mg/kg/day), and the other (control) group was fed on a 1% cholesterol diet only. At the end of the 14 week period, all animals were killed and autopsied. There was no difference in serum total cholesterol between the La3+-treated rabbits and the control rabbits through the experimental period. Serum triglyceride, phospholipid, HDL-cholesterol, total protein, and albumin levels were also similar in both groups through the study period. LaCl3 was well tolerated and the increases of body weight did not differ significantly between the groups. LaCl3 had no effects on arterial pressure. Serum calcium and inorganic phosphorus were similar in both groups through the study. Serum calcium increased after six weeks and then returned to normal. Serum inorganic phosphorus increased after two weeks but decreased at six weeks and then returned to normal level. 1% Cholesterol diet itself might have influence on the metabolism of calcium and inorganic phosphorus. Platelet aggregability measured by screen filtration pressure method was inhibited significantly at the end of the study in the La3+-treated rabbits. La3+ by itself had no significant effects on platelet aggregation in vitro. Aortic lesions stainable with Sudan II covered 36.3±8.6% of the intimal surface in the control rabbits, and 25.4±5.5% in the La3+-treated rabbits. Histopathologically, intimal foam cell layer was thicker in the control rabbits than in the La3+-treated rabbits. Relative plaque deposition of intramural coronary arteries was similar in both groups. Fatty degeneration of the liver was suppressed in the La3+-treated rabbits. Although our results were not so remarkable as those of D. M. Kramsch et al., we are sure that La3+ suppressed experimental atherosclerosis in rabbits without reducing hypercholesterolemia. Inhibitory effects of other Ca2+-channel blockers on experimental atherosclerosis and the mechanisms of these drugs are currently being studied by us.
  • Editor: Japan Atherosclerosis Society
  • Idioma: Japonês;Inglês
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