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Defining Memory CD8 T Cell

Martin, Matthew D ; Badovinac, Vladimir P

Frontiers in immunology, 2018-11, Vol.9, p.2692-2692 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Defining Memory CD8 T Cell
  • Autor: Martin, Matthew D ; Badovinac, Vladimir P
  • Assuntos: Aging - immunology ; Animals ; CD8 T cell ; CD8-Positive T-Lymphocytes - cytology ; CD8-Positive T-Lymphocytes - immunology ; heterogeneity ; Humans ; Immunologic Memory - physiology ; Immunology ; memory ; Mice ; Models, Immunological ; outbred mice ; protection ; subsets
  • É parte de: Frontiers in immunology, 2018-11, Vol.9, p.2692-2692
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Reviewed by: Kimberly Sue Schluns, University of Texas MD Anderson Cancer Center, United States; Vandana Kalia, University of Washington, United States
    This article was submitted to Immunological Memory, a section of the journal Frontiers in Immunology
    Edited by: Weiguo Cui, Bloodcenter of Wisconsin, United States
  • Descrição: CD8 T cells comprising the memory pool display considerable heterogeneity, with individual cells differing in phenotype and function. This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities. Recent data suggest that phenotype and/or function of numerically stable circulatory memory CD8 T cells are defined by the age of memory CD8 T cell (or time after initial antigen-encounter). In addition, history of antigen stimulations has a profound effect on memory CD8 T cell populations, suggesting that repeated infections (or vaccination) have the capacity to further shape the memory CD8 T cell pool. Finally, genetic background of hosts and history of exposure to diverse microorganisms likely contribute to the observed heterogeneity in the memory CD8 T cell compartment. Extending our tool box and exploring alternative mouse models (i.e., "dirty" and/or outbred mice) to encompass and better model diversity observed in humans will remain an important goal for the near future that will likely shed new light into the mechanisms that govern biology of memory CD8 T cells.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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