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Apocynin protects against neurological damage induced by quinolinic acid by an increase in glutathione synthesis and Nrf2 levels

Cruz-Álvarez, Silvia ; Santana-Martínez, Ricardo ; Avila-Chávez, Euclides ; Barrera-Oviedo, Diana ; Hernández-Pando, Rogelio ; Pedraza-Chaverri, José ; Maldonado, Perla D

Neuroscience, 2017-05, Vol.350, p.65-74 [Periódico revisado por pares]

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Título:
Apocynin protects against neurological damage induced by quinolinic acid by an increase in glutathione synthesis and Nrf2 levels
Autor: Cruz-Álvarez, Silvia ; Santana-Martínez, Ricardo ; Avila-Chávez, Euclides ; Barrera-Oviedo, Diana ; Hernández-Pando, Rogelio ; Pedraza-Chaverri, José ; Maldonado, Perla D
Assuntos: Acetophenones - pharmacology ; Animals ; Antioxidants - pharmacology ; apocynin ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; glutathione ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Male ; Neurology ; NF-E2-Related Factor 2 - metabolism ; Nrf2 factor ; quinolinic acid ; Quinolinic Acid - pharmacology ; Rats, Wistar
É parte de: Neuroscience, 2017-05, Vol.350, p.65-74
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Highlights • APO treatment decreased the QUIN-induced histological damage. • APO treatment increased GSH levels and the activity of GSH metabolism-related enzymes in striatum of rats. • APO treatment increased Nrf2 expression.
Editor: United States: Elsevier Ltd
Idioma: Inglês

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