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Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica

Bello, Bello Aminu ; Khan, Shahid Ali ; Khan, Jalaluddin Awllia ; Syed, Fareeduddin Quadri ; Mirza, Muqtadir Baig ; Shah, Luqman ; Khan, Sher Bahadar

Biochemical and biophysical research communications, 2017-08, Vol.490 (3), p.889-894 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica
Autor: Bello, Bello Aminu ; Khan, Shahid Ali ; Khan, Jalaluddin Awllia ; Syed, Fareeduddin Quadri ; Mirza, Muqtadir Baig ; Shah, Luqman ; Khan, Sher Bahadar
Assuntos: Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial ; Anticancer ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Arecaceae - chemistry ; Cell Line, Tumor ; Coloring Agents - chemistry ; Coloring Agents - isolation & purification ; Congo Red - chemistry ; Congo Red - isolation & purification ; Environmental Pollutants - chemistry ; Environmental Pollutants - isolation & purification ; Escherichia coli - metabolism ; Escherichia coli Infections - drug therapy ; Fruit - chemistry ; Humans ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Neoplasms - drug therapy ; Nitrophenols - chemistry ; Nitrophenols - isolation & purification ; Oxidation-Reduction ; Plant Extracts - chemistry ; Reduction reaction ; SEM ; Silver - chemistry ; Silver - pharmacology ; Silver nanoparticles ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus - drug effects ; TEM
É parte de: Biochemical and biophysical research communications, 2017-08, Vol.490 (3), p.889-894
Descrição: We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, FESEM and EDS respectively. The anti-proliferation activity of the synthesized AgNps was carried out using MTT assay on human prostate (PC3), breast (MCF7) and liver (HepG2) cancer cell lines. The anti-proliferation assay showed that the AgNps were able to inhibit the proliferation of the cancer cell lines in a dose depending manner. The effect was found more pronounced on prostate (IC50 2.6 mg/mL) followed by breast (IC50 4.8 mg/mL) and then liver cancer cell lines (IC50 6.8 mg/mL). The prepared AgNps were found to inhibit 99% growth of both E. coli and S. aureus after 24 h of incubation. The nanoparticles were used for the degradation of 4-nitrophenol (4-NP) and Congo red dyes (CR), which efficiently degrade CR, but make complex formation with 4-NP. Therefore, the AgNps synthesized from the aqueous fruit extract of H. thebaica have potential application in pharmacology and waste water treatment. Graphical abstract for the synthesis of AgNps and their anti-cancer, bactericidal and organic pollutants degradation activity. [Display omitted] •Synthesis of fruit extract based AgNps.•AgNps characterization by TEM, SEM, EDS, XRD and FTIR methods.•Anticancer effect of the Nps on human PC3, MCF7 and HepG2 cells.•Antibacterial effect of the Nps on E. coli and S. aureus.•Catalytic activity of the AgNps on some organic pollutants.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica

Bello, Bello Aminu ; Khan, Shahid Ali ; Khan, Jalaluddin Awllia ; Syed, Fareeduddin Quadri ; Mirza, Muqtadir Baig ; Shah, Luqman ; Khan, Sher Bahadar

United States: Elsevier Inc

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