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Human monocyte activation by supernatants from continuous cultures of Plasmodium falciparum

Abdalla, S.H. ; Wickramasinghe, S.N.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Vol.79 (5), p.657-662 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Human monocyte activation by supernatants from continuous cultures of Plasmodium falciparum
Autor: Abdalla, S.H. ; Wickramasinghe, S.N.
Assuntos: Adult ; Biological and medical sciences ; DNA - biosynthesis ; Erythrocytes ; Fundamental and applied biological sciences. Psychology ; Human protozoal diseases ; Humans ; Immunoglobulin G - immunology ; In Vitro Techniques ; Infectious diseases ; Life cycle. Host-agent relationship. Pathogenesis ; Malaria ; Medical sciences ; Methotrexate - pharmacology ; Monocytes - immunology ; Parasitic diseases ; Phagocytosis ; Plasmodium falciparum - immunology ; Protozoa ; Protozoal diseases ; T-Lymphocytes - immunology ; Tropical medicine
É parte de: Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Vol.79 (5), p.657-662
Notas: ark:/67375/HXZ-P6NVZRGN-0
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: When mononuclear cells derived from the blood of unsensitized adult Caucasians are incubated for 22 hours with supernatants from cultures of Plasmodium falciparum, there is a substantial stimulation of the phagocytic capacity of the adherent monocytes for anti-D sensitized red cells. This stimulatory effect is dependent on (i) a heat-stable factor in such supernatants, (ii) the presence of T lymphocytes in the mononuclear cell preparations and (iii) the occurrence of DNA synthesis in the mononuclear cell cultures. It is proposed that the malaria culture supernatant contains a mitogen which acts on non-allergized T lymphocytes and that the stimulation of such lymphocytes probably causes the release of a lymphokine which enhances the phagocytic activity of cells of the mononuclear phagocyte system.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Human monocyte activation by supernatants from continuous cultures of Plasmodium falciparum

Abdalla, S.H. ; Wickramasinghe, S.N.

Oxford: Elsevier Ltd

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