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SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer

Xu, T-P ; Liu, X-X ; Xia, R ; Yin, L ; Kong, R ; Chen, W-M ; Huang, M-D ; Shu, Y-Q

Oncogene, 2015-11, Vol.34 (45), p.5648-5661 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer
Autor: Xu, T-P ; Liu, X-X ; Xia, R ; Yin, L ; Kong, R ; Chen, W-M ; Huang, M-D ; Shu, Y-Q
Assuntos: Analysis ; Apoptosis ; Cancer therapies ; Carcinoma ; Care and treatment ; Cell growth ; Cell Line, Tumor ; Cell Proliferation ; Complications and side effects ; Cyclin-dependent kinase ; Cyclin-Dependent Kinase Inhibitor p15 - genetics ; Cyclin-Dependent Kinase Inhibitor p15 - metabolism ; Cyclin-Dependent Kinase Inhibitor p21 - genetics ; Cyclin-Dependent Kinase Inhibitor p21 - metabolism ; Cyclin-dependent kinases ; Cytoskeletal Proteins - genetics ; Cytoskeletal Proteins - metabolism ; Development and progression ; Gastric cancer ; Gene expression ; Gene silencing ; Humans ; Kinases ; Krueppel-like factor ; Kruppel-Like Transcription Factors - biosynthesis ; Kruppel-Like Transcription Factors - genetics ; mRNA stability ; Proteins ; Ribonucleic acid ; RNA ; RNA Stability ; RNA, Long Noncoding - biosynthesis ; RNA, Long Noncoding - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA, Neoplasm - genetics ; RNA, Neoplasm - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Sp1 protein ; Sp1 Transcription Factor - genetics ; Sp1 Transcription Factor - metabolism ; Stomach cancer ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Therapeutic applications ; Tumorigenesis ; Tumorigenicity
É parte de: Oncogene, 2015-11, Vol.34 (45), p.5648-5661
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The long noncoding RNA TINCR shows aberrant expression in human squamous carcinomas. However, its expression and function in gastric cancer remain unclear. We report that TINCR is strongly upregulated in human gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression. We also revealed that TINCR overexpression is induced by nuclear transcription factor SP1. Silencing TINCR expression inhibited cell proliferation, colony formation, tumorigenicity and apoptosis promotion, whereas TINCR overexpression promoted cell growth, as documented in the SGC7901 and BGC823 cell lines. Mechanistic analyses indicated that TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression, then KLF2 regulated cyclin-dependent kinase genes CDKN1A/P21 and CDKN2B/P15 transcription and expression, thereby affecting the proliferation and apoptosis of GC cells. Together, our findings suggest that TINCR contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease.
Editor: England: Nature Publishing Group
Idioma: Inglês

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SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer

Xu, T-P ; Liu, X-X ; Xia, R ; Yin, L ; Kong, R ; Chen, W-M ; Huang, M-D ; Shu, Y-Q

England: Nature Publishing Group

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