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Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency

Cardoso, Daniela F ; Martinelli, Jr, Carlos Eduardo ; Campos, Viviane C ; Gomes, Elenilde S ; Rocha, Ivina E S ; Oliveira, Carla R P ; Vicente, Taisa A R ; Pereira, Rossana M C ; Pereira, Francisco A ; Cartaxo, Carla K A ; Milani, Soraya L S ; Oliveira, Mario C P ; Melo, Enaldo V ; Oliveira, Andre L P ; Aguiar-Oliveira, Manuel H

Arquivos brasileiros de endocrinologia e metabologia, 2014-02, Vol.58 (1), p.23-29

Brazil: Sociedade Brasileira de Endocrinologia e Metabologia

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Título:
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency
Autor: Cardoso, Daniela F ; Martinelli, Jr, Carlos Eduardo ; Campos, Viviane C ; Gomes, Elenilde S ; Rocha, Ivina E S ; Oliveira, Carla R P ; Vicente, Taisa A R ; Pereira, Rossana M C ; Pereira, Francisco A ; Cartaxo, Carla K A ; Milani, Soraya L S ; Oliveira, Mario C P ; Melo, Enaldo V ; Oliveira, Andre L P ; Aguiar-Oliveira, Manuel H
Assuntos: Adolescent ; Age Determination by Skeleton ; Analysis of Variance ; Body Height - drug effects ; Body Mass Index ; Brazil ; Child ; ENDOCRINOLOGY & METABOLISM ; Human Growth Hormone - blood ; Human Growth Hormone - therapeutic use ; Humans ; Insulin-Like Growth Factor I - analysis ; Laron Syndrome - drug therapy ; Luminescent Measurements ; Recombinant Proteins - therapeutic use ; Retrospective Studies
É parte de: Arquivos brasileiros de endocrinologia e metabologia, 2014-02, Vol.58 (1), p.23-29
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD. Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS). Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1 st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD. GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD.
Editor: Brazil: Sociedade Brasileira de Endocrinologia e Metabologia
Idioma: Inglês;Português

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Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency

Brazil: Sociedade Brasileira de Endocrinologia e Metabologia

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