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Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice

Zhang, Xi ; Wang, Die ; Zheng, Yafei ; Tu, Yingxin ; Xu, Qingqing ; Jiang, Haowei ; Li, Chen ; Zhao, Liangcai ; Li, Yuping ; Zheng, Hong ; Gao, Hongchang

Biochimica et biophysica acta. Molecular basis of disease, 2021-12, Vol.1867 (12), p.166266-166266, Article 166266 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice
Autor: Zhang, Xi ; Wang, Die ; Zheng, Yafei ; Tu, Yingxin ; Xu, Qingqing ; Jiang, Haowei ; Li, Chen ; Zhao, Liangcai ; Li, Yuping ; Zheng, Hong ; Gao, Hongchang
Assuntos: Animals ; Correlation network ; Diabetes ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - pathology ; Fatty Acids, Volatile - genetics ; Fatty Acids, Volatile - metabolism ; Female ; Gastrointestinal Microbiome - genetics ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Metabolome - genetics ; Metabolomics ; Mice ; Mice, Inbred NOD - genetics ; Mice, Inbred NOD - metabolism ; Microbiome ; Sex Characteristics ; Sex difference
É parte de: Biochimica et biophysica acta. Molecular basis of disease, 2021-12, Vol.1867 (12), p.166266-166266, Article 166266
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Descrição: Sexual dimorphism exists in the onset and development of type 1 diabetes (T1D), but its potential pathological mechanism is poorly understood. In the present study, we examined sex-specific changes in the gut microbiome and host metabolome of T1D mice via 16S rRNA gene sequencing and nuclear magnetic resonance (NMR)-based metabolomics approach, and aimed to investigate potential mechanism of the gut microbiota-host metabolic interaction in the sexual dimorphism of T1D. Our results demonstrate that female mice had a greater shift in the gut microbiota than male mice during the development of T1D; however, host metabolome was more susceptible to T1D in male mice. The correlation network analysis indicates that T1D-induced host metabolic changes may be regulated by the gut microbiota in a sex-specific manner, mainly involving short-chain fatty acids (SCFAs) metabolism, energy metabolism, amino acid metabolism, and choline metabolism. Therefore, our study suggests that sex-dependent “gut microbiota-host metabolism axis” may be implicated in the sexual dimorphism of T1D, and the link between microbes and metabolites might contribute to the prevention and treatment of T1D. •Male mice have more typical type 1 diabetic symptoms than female mice.•The gut microbial shifts are more significant in female mice during T1D progress.•Male mice show larger changes in serum/liver metabolism during T1D progress.•Host metabolism may be modulated by the gut microbiota in a sex-specific manner.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice

Zhang, Xi ; Wang, Die ; Zheng, Yafei ; Tu, Yingxin ; Xu, Qingqing ; Jiang, Haowei ; Li, Chen ; Zhao, Liangcai ; Li, Yuping ; Zheng, Hong ; Gao, Hongchang

Netherlands: Elsevier B.V

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