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CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

Pandiyan, Pushpa ; Conti, Heather R. ; Zheng, Lixin ; Peterson, Alanna C. ; Mathern, Douglas R. ; Hernández-Santos, Nydiaris ; Edgerton, Mira ; Gaffen, Sarah L. ; Lenardo, Michael J.

Immunity (Cambridge, Mass.), 2011-03, Vol.34 (3), p.422-434 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model
Autor: Pandiyan, Pushpa ; Conti, Heather R. ; Zheng, Lixin ; Peterson, Alanna C. ; Mathern, Douglas R. ; Hernández-Santos, Nydiaris ; Edgerton, Mira ; Gaffen, Sarah L. ; Lenardo, Michael J.
Assuntos: Animals ; Candida albicans - immunology ; Candidiasis - immunology ; CD4 Antigens - immunology ; Cell Differentiation ; Disease Models, Animal ; Forkhead Transcription Factors - immunology ; Immunity, Innate ; Interleukin-2 Receptor alpha Subunit - immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory - immunology ; Th17 Cells - cytology ; Th17 Cells - immunology
É parte de: Immunity (Cambridge, Mass.), 2011-03, Vol.34 (3), p.422-434
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively. Here we explore why under Th17 cell polarizing conditions, Treg cells did not suppress, but rather upregulated, the expression of interleukin-17A (IL-17A), IL-17F, and IL-22 from responding CD4+ T cells (Tresp cells). Upregulation of IL-17 cytokines in Tresp cells was dependent on consumption of IL-2 by Treg cells, especially at early time points both in vitro and in vivo. During an oral Candida albicans infection in mice, Treg cells induced IL-17 cytokines in Tresp cells, which markedly enhanced fungal clearance and recovery from infection. These findings show how Treg cells can promote acute Th17 cell responses to suppress mucosal fungus infections and reveal that Treg cells have a powerful capability to fight infections besides their role in maintaining tolerance or immune homeostasis. ► Treg cells boost IL-17 cytokines in Th17 cells by consuming IL-2 in vitro and in vivo ► Treg cells enhance acute Th17 cell response against Candida albicans ► Treg cells inhibit Th17 cells in a delayed manner in model of IBD
Editor: United States: Elsevier Inc
Idioma: Inglês

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CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

Pandiyan, Pushpa ; Conti, Heather R. ; Zheng, Lixin ; Peterson, Alanna C. ; Mathern, Douglas R. ; Hernández-Santos, Nydiaris ; Edgerton, Mira ; Gaffen, Sarah L. ; Lenardo, Michael J.

United States: Elsevier Inc

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