skip to main content
Idioma:

IL-15/IL-15Rα-Mediated Avidity Maturation of Memory CD8+ T Cells

Oh, SangKon ; Perera, Liyanage P. ; Burke, Donald S. ; Waldmann, Thomas A. ; Berzofsky, Jay A.

Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (42), p.15154-15159 [Revista revisada por pares]

National Academy of Sciences

Texto completo disponible

Citas Citado por
  • Título:
    IL-15/IL-15Rα-Mediated Avidity Maturation of Memory CD8+ T Cells
  • Autor: Oh, SangKon ; Perera, Liyanage P. ; Burke, Donald S. ; Waldmann, Thomas A. ; Berzofsky, Jay A.
  • Materias: Antibodies ; Antigens ; Biological Sciences ; Cell lines ; Molecules ; Spleen ; Splenocytes ; T cell antigen receptors ; T lymphocytes ; Vaccination ; Viruses
  • Es parte de: Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (42), p.15154-15159
  • Notas: Abbreviations: CTL, cytotoxic T lymphocyte; TCR, T cell receptor; CFSE, carboxy fluorescein (diacetate) succinimidyl ester.
    To whom correspondence should be addressed at: Vaccine Branch, National Cancer Institute, Building 10, Room 6B-12 (MSC-1578), National Institutes of Health, Bethesda, MD 20892-1578. E-mail: berzofsk@helix.nih.gov.
    Contributed by Thomas A. Waldmann, September 13, 2004
  • Descripción: T cell avidity is critical to viral clearance, but mechanisms of CD8+ T cell avidity maturation are poorly understood. Here, we find that IL-15 mediates two mechanisms of avidity maturation. (i) By selection at the population level, IL-15 promotes greater survival of high- compared with low-avidity cytotoxic T lymphocytes (CTLs). High-avidity CTLs express higher levels of IL-15Rα and persist longer by homeostatic proliferation. (ii) At the individual cell level, IL-15 induces higher levels of surface coreceptor CD8αβ, increasing functional avidity. IL-15 during priming selects or induces higher-avidity CTLs. Conversely, high-avidity CTLs are diminished in IL-15Rα knockout mice. These results provide an explanation of CD8+ T cell avidity maturation and may contribute to the design of novel vaccines.
  • Editor: National Academy of Sciences
  • Idioma: Inglés
Volver a la lista de resultados
Ir a la página anteriorAnterior Resultado  9 SiguienteIr a la siguiente página

  • Realización: ABCD-USP USP   Logos de Redes Sociales: Freepik

Buscando en bases de datos remotas, por favor espere

  • Buscando por
  • enscope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
  • Mostrar lo que tiene hasta ahora