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Peripheral and Central Sensitization of Pain in Individuals With Hand Osteoarthritis and Associations With Self‐Reported Pain Severity

Steen Pettersen, Pernille ; Neogi, Tuhina ; Magnusson, Karin ; Berner Hammer, Hilde ; Uhlig, Till ; Kvien, Tore K. ; Haugen, Ida K.

Arthritis & rheumatology (Hoboken, N.J.), 2019-07, Vol.71 (7), p.1070-1077 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
Peripheral and Central Sensitization of Pain in Individuals With Hand Osteoarthritis and Associations With Self‐Reported Pain Severity
Autor: Steen Pettersen, Pernille ; Neogi, Tuhina ; Magnusson, Karin ; Berner Hammer, Hilde ; Uhlig, Till ; Kvien, Tore K. ; Haugen, Ida K.
Assuntos: Aged ; Arthritis ; Biocompatibility ; Central Nervous System Sensitization - physiology ; Clinical Medicine ; Confidence intervals ; Demographics ; Demography ; Female ; Hand ; Hand Joints ; Health Sciences ; Humans ; Hälsovetenskap ; Joints (anatomy) ; Klinisk medicin ; Linear Models ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Muscles ; Osteoarthritis ; Osteoarthritis - complications ; Osteoarthritis - physiopathology ; Pain ; Pain - etiology ; Pain - physiopathology ; Pain Measurement ; Pain Threshold ; Physiotherapy ; Postsynaptic Potential Summation - physiology ; Regression analysis ; Regression models ; Reumatologi och inflammation ; Rheumatology and Autoimmunity ; Self Report ; Sensory testing ; Sjukgymnastik ; Skeletal muscle ; Statistical analysis ; Wrist
É parte de: Arthritis & rheumatology (Hoboken, N.J.), 2019-07, Vol.71 (7), p.1070-1077
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Contributors Substantial contributions to study conception/design, or acquisition/analysis of data: PSP, TN, KM, TKK and IKH. Interpretation of data and drafting of the manuscript or revising it critically: PSP, TN, KM, HBH, TU, TKK and IKH. Final approval of the publication: PSP, TN, KM, HBH, TKK and IKH.
Author notes Preliminary results from this study have been published in abstract form; Steen Pettersen P et al. Sensitization and pain severity in patients with hand osteoarthritis – Data from the Nor-Hand study [abstract 89]. Osteoarthritis Cartilage 2018;26(Suppl 1):58–9, and Steen Pettersen P et al. Sensitization and pain severity in patients with hand osteoarthritis [abstract SAT0574]. Ann Rheum Dis 2018;77(Suppl):1141.
Descrição: Objective Pain sensitization, an important osteoarthritis (OA) pain mechanism, has not been substantially investigated in patients with hand OA. It is unknown how peripheral and central sensitization are related to self‐reported hand pain. Methods Individuals with verified hand OA in the Nor‐Hand study underwent quantitative sensory testing of pressure pain thresholds (PPTs) locally (painful and nonpainful finger joints) and remotely (wrist, trapezius, and tibialis anterior muscles), and testing of temporal summation (TS), a manifestation of central sensitization. We examined cross‐sectional associations of PPT tertiles and TS with hand pain using the Numerical Rating Scale (NRS) (range 0–10) and the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain subscale (range 0–20). Linear regression models were adjusted for demographics, psychosocial factors, and radiographic severity. Results This study included 282 participants (88% female) with a median age of 61 years (interquartile range [IQR] 57–66). Participants with the lowest PPTs in their finger joints and in most remote locations reported higher NRS pain values, compared to patients with the highest PPTs, with adjusted β values ranging from 0.6 (95% confidence interval [95% CI] 0.0, 1.2) to 0.9 (95% CI 0.3, 1.5). The 118 participants (42%) with TS reported higher mean ± SD NRS pain values compared to those without TS (4.1 ± 2.4 versus 3.1 ± 1.7; adjusted β = 0.6 [95% CI 0.2, 1.1]). Neither PPTs nor the presence of TS were associated with AUSCAN pain. Conclusion Central sensitization was common in patients with hand OA. Lower local and widespread PPTs and the presence of TS were associated with higher hand pain intensity, even after adjustment for demographics, psychosocial factors, and radiographic severity. Sensitization may therefore represent a possible treatment target.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês;Norueguês

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Peripheral and Central Sensitization of Pain in Individuals With Hand Osteoarthritis and Associations With Self‐Reported Pain Severity

Steen Pettersen, Pernille ; Neogi, Tuhina ; Magnusson, Karin ; Berner Hammer, Hilde ; Uhlig, Till ; Kvien, Tore K. ; Haugen, Ida K.

United States: Wiley Subscription Services, Inc

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