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Transcranial laser stimulation improves human cerebral oxygenation

Tian, Fenghua ; Hase, Snehal N. ; Gonzalez-Lima, F. ; Liu, Hanli

Lasers in surgery and medicine, 2016-04, Vol.48 (4), p.343-349 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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  • Título:
    Transcranial laser stimulation improves human cerebral oxygenation
  • Autor: Tian, Fenghua ; Hase, Snehal N. ; Gonzalez-Lima, F. ; Liu, Hanli
  • Assuntos: Adolescent ; Adult ; Biomarkers - metabolism ; Brain - metabolism ; Brain - radiation effects ; brain tissue oxygenation ; Clinical Report ; Clinical Reports ; Female ; functional near-infrared spectroscopy (fNIRS) ; Healthy Volunteers ; Hemodynamics - radiation effects ; Hemoglobins - metabolism ; Humans ; low-level laser therapy (LLLT) ; Low-Level Light Therapy - methods ; Male ; Oxygen - metabolism ; photobiomodulation ; Spectroscopy, Near-Infrared - methods ; Young Adult
  • É parte de: Lasers in surgery and medicine, 2016-04, Vol.48 (4), p.343-349
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    Conflict of Interest Disclosures: Dr. Gonzalez‐Lima reported receiving support from an institutional research fellowship from the College of Liberal Arts of the University of Texas at Austin. Dr. Gonzalez‐Lima holds the George I. Sanchez Centennial Endowed Professorship in Liberal Arts and Sciences. Dr. Tian, M.S. Hase, and Dr. Liu had no disclosures to report.
  • Descrição: Background and Objective Transcranial laser stimulation of the brain with near‐infrared light is a novel form of non‐invasive photobiomodulation or low‐level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neurophysiological effects is essential for mechanistic study and treatment evaluation. This study investigated how transcranial laser stimulation influences cerebral hemodynamics and oxygenation in the human brain in vivo using functional near‐infrared spectroscopy (fNIRS). Materials and Methods Two separate experiments were conducted in which 1,064‐nm laser stimulation was administered at (1) the center and (2) the right side of the forehead, respectively. The laser emitted at a power of 3.4 W and in an area of 13.6 cm2, corresponding to 0.25 W/cm2 irradiance. Stimulation duration was 10 minutes. Nine healthy male and female human participants of any ethnic background, in an age range of 18–40 years old were included in each experiment. Results In both experiments, transcranial laser stimulation induced an increase of oxygenated hemoglobin concentration (Δ[HbO2]) and a decrease of deoxygenated hemoglobin concentration (Δ[Hb]) in both cerebral hemispheres. Improvements in cerebral oxygenation were indicated by a significant increase of differential hemoglobin concentration (Δ[HbD] = Δ[HbO2] − Δ[Hb]). These effects increased in a dose‐dependent manner over time during laser stimulation (10 minutes) and persisted after laser stimulation (6 minutes). The total hemoglobin concentration (Δ[HbT] = Δ[HbO2] + Δ[Hb]) remained nearly unchanged in most cases. Conclusion Near‐infrared laser stimulation applied to the forehead can transcranially improve cerebral oxygenation in healthy humans. Lasers Surg. Med. 48:343–349, 2016. © 2016 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.
  • Editor: United States: Blackwell Publishing Ltd
  • Idioma: Inglês
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