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Elevated mazes as animal models of anxiety: effects of serotonergic agents

Pinheiro, Simone H ; Zangrossi, Jr, Hélio ; Del-Ben, Cristina M ; Graeff, Frederico G

Anais da Academia Brasileira de Ciências, 2007-03, Vol.79 (1), p.71-85 [Periódico revisado por pares]

Brazil: Academia Brasileira de Ciências

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  • Título:
    Elevated mazes as animal models of anxiety: effects of serotonergic agents
  • Autor: Pinheiro, Simone H ; Zangrossi, Jr, Hélio ; Del-Ben, Cristina M ; Graeff, Frederico G
  • Assuntos: animal model ; Animals ; ansiedade ; anxiety ; Anxiety - drug therapy ; Anxiety - physiopathology ; Disease Models, Animal ; elevated maze ; Escape Reaction - drug effects ; Escape Reaction - physiology ; labirinto elevado ; Mice ; modelo animal ; MULTIDISCIPLINARY SCIENCES ; panic ; pânico ; Rats ; serotonin ; Serotonin - physiology ; Serotonin Agents - pharmacology ; serotonina
  • É parte de: Anais da Academia Brasileira de Ciências, 2007-03, Vol.79 (1), p.71-85
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: This article reviews reported results about the effects of drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, intracerebral drug administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the drug effects on the one-way escape task in the elevated T-maze predict the drug response of panic disorder patients. Overall, the drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder.
  • Editor: Brazil: Academia Brasileira de Ciências
  • Idioma: Inglês;Português
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