skip to main content
Idioma:

Xanthone Derivatives: New Insights in Biological Activities

Pinto, M M M ; Sousa, M E ; Nascimento, M S J

Current medicinal chemistry, 2005-10, Vol.12 (21), p.2517-2538 [Periódico revisado por pares]

United Arab Emirates: Bentham Science Publishers Ltd

Texto completo disponível

Citações Citado por
  • Título:
    Xanthone Derivatives: New Insights in Biological Activities
  • Autor: Pinto, M M M ; Sousa, M E ; Nascimento, M S J
  • Assuntos: Xanthones - chemistry ; Xanthones - pharmacology
  • É parte de: Current medicinal chemistry, 2005-10, Vol.12 (21), p.2517-2538
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Xanthones or 9H-xanthen-9-ones (dibenzo-γ-pirone) comprise an important class of oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological activities of this class of compounds are associated with their tricyclic scaffold but vary depending on the nature and/or position of the different substituents. In this review, an array of biological/pharmacological effects is presented for both natural and synthetic xanthone derivatives, with an emphasis on some significant studies on structure-activity relationships. The antitumor activity of some xanthones as well as the related targets, particularly PKC modulation studies, is also discussed in detail. Examples of the "hit" compounds involved in cancer therapy, namely DMXAA, psorospermin, mangiferin, norathyriol, mangostins, and AH6809, a prostanoid receptor antagonist, are also mentioned. Finally, a historical perspective of these xanthonic derivatives, their relevance as therapeutic agents and/or their uses as pharmacological tools and as extract components in folk medicine are also highlighted.
  • Editor: United Arab Emirates: Bentham Science Publishers Ltd
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.