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Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

Feller, L ; Khammissa, R A G ; Kramer, B ; Altini, M ; Lemmer, J

Head & face medicine, 2016-02, Vol.12 (11), p.11-11, Article 11 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Autor: Feller, L ; Khammissa, R A G ; Kramer, B ; Altini, M ; Lemmer, J
Assuntos: Basal cell carcinoma ; Carcinoma, Basal Cell - etiology ; Carcinoma, Basal Cell - immunology ; Carcinoma, Basal Cell - pathology ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - pathology ; Care and treatment ; Cell cycle ; Complications and side effects ; Dentistry ; Deoxyribonucleic acid ; DNA ; Funding ; Genes ; Hair ; Head and Neck Neoplasms - etiology ; Head and Neck Neoplasms - immunology ; Head and Neck Neoplasms - pathology ; Humans ; Immune system ; Kinases ; Melanoma ; Melanoma - etiology ; Melanoma - immunology ; Melanoma - pathology ; Mutation ; Pathogenesis ; Review ; Risk Factors ; Skin cancer ; Skin Neoplasms - etiology ; Skin Neoplasms - immunology ; Skin Neoplasms - pathology ; Squamous cell carcinoma ; Ultraviolet radiation ; Ultraviolet Rays - adverse effects
É parte de: Head & face medicine, 2016-02, Vol.12 (11), p.11-11, Article 11
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways.Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the pathogenesis of cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma apart from their role in determining a cancer-prone pigmentory phenotype (fair skin, red hair, blue eyes) through their interactions with other genes regulating immuno-inflammatory responses, DNA repair or apoptosis.In this short review we focus on the aetiological role of UV in cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin, and on some associated biopathological events.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

Feller, L ; Khammissa, R A G ; Kramer, B ; Altini, M ; Lemmer, J

England: BioMed Central Ltd

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