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Genetically Engineered Phages: a Review of Advances over the Last Decade

Pires, Diana P ; Cleto, Sara ; Sillankorva, Sanna ; Azeredo, Joana ; Lu, Timothy K

Microbiology and molecular biology reviews, 2016-09, Vol.80 (3), p.523-543 [Periódico revisado por pares]

United States: American Society for Microbiology

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  • Título:
    Genetically Engineered Phages: a Review of Advances over the Last Decade
  • Autor: Pires, Diana P ; Cleto, Sara ; Sillankorva, Sanna ; Azeredo, Joana ; Lu, Timothy K
  • Assuntos: Antimicrobial agents ; Bacteria - virology ; Bacteriophages - genetics ; Biological activity ; CRISPR-Cas Systems ; DNA, Viral - genetics ; Drug Delivery Systems ; Genetic engineering ; Genetic Engineering - methods ; Genome, Viral - genetics ; Molecular biology ; Multidrug resistant organisms ; Phage Therapy ; Reviews ; Viruses
  • É parte de: Microbiology and molecular biology reviews, 2016-09, Vol.80 (3), p.523-543
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-2
    Citation Pires DP, Cleto S, Sillankorva S, Azeredo J, Lu TK. 2016. Genetically engineered phages: a review of advances over the last decade. Microbiol Mol Biol Rev 80:523–543. doi:10.1128/MMBR.00069-15.
  • Descrição: Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized. The nascent field of phage therapy was adversely affected by inadequately controlled trials and the discovery of antibiotics. Although the study of phages as anti-infective agents slowed, phages played an important role in the development of molecular biology. In recent years, the increase in multidrug-resistant bacteria has renewed interest in the use of phages as antimicrobial agents. With the wide array of possibilities offered by genetic engineering, these bacterial viruses are being modified to precisely control and detect bacteria and to serve as new sources of antibacterials. In applications that go beyond their antimicrobial activity, phages are also being developed as vehicles for drug delivery and vaccines, as well as for the assembly of new materials. This review highlights advances in techniques used to engineer phages for all of these purposes and discusses existing challenges and opportunities for future work.
  • Editor: United States: American Society for Microbiology
  • Idioma: Inglês
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