Idioma:

Vitamin D3 availability and functional activity of peripheral blood phagocytes in experimental type 1 diabetes

Labudzyns'kyĭ, D O ; Shymans'kyĭ, I O ; Riasnyĭ, V M ; Velykyĭ, M M

Ukrainian biochemical journal, 2014-03, Vol.86 (2), p.107-118 [Periódico revisado por pares]

Ukraine

Texto completo disponível

Citações Citado por

Enviar para

Título:
Vitamin D3 availability and functional activity of peripheral blood phagocytes in experimental type 1 diabetes
Autor: Labudzyns'kyĭ, D O ; Shymans'kyĭ, I O ; Riasnyĭ, V M ; Velykyĭ, M M
Assuntos: Animals ; Cholecalciferol - administration & dosage ; Cholecalciferol - blood ; Cholestanetriol 26-Monooxygenase - genetics ; Cholestanetriol 26-Monooxygenase - metabolism ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - enzymology ; Diabetes Mellitus, Experimental - immunology ; Escherichia coli - immunology ; Gene Expression ; Granulocytes - drug effects ; Granulocytes - immunology ; Liver - drug effects ; Liver - enzymology ; Liver - immunology ; Male ; Mice ; Mice, Inbred C57BL ; Monocytes - drug effects ; Monocytes - immunology ; Phagocytosis - drug effects ; Reactive Nitrogen Species - immunology ; Reactive Nitrogen Species - metabolism ; Reactive Oxygen Species - immunology ; Reactive Oxygen Species - metabolism ; Streptozocin ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - enzymology ; Vitamin D Deficiency - immunology
É parte de: Ukrainian biochemical journal, 2014-03, Vol.86 (2), p.107-118
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The study was devoted to identifying the relation between vitamin D3 availability (assessed by the level of circulatory 25OHD3), content of vitamin D3 25-hydroxylase isozymes CYP27A1 and CYP2R1 in hepatic tissue and functional activity of peripheral blood phagocytes in mice with experimental type 1 diabetes. It has been shown that diabetes is accompanied by the development of vitamin D3-deficiency which is characterized by decreased 25OHD3 content in blood serum and determined by changes in tissue expression of the major isoforms of vitamin D3 25-hydroxylase. The level of hepatic CYP27A1 was revealed to be markedly reduced with a concurrent significant augmentation of CYP2R1. Cholecalciferol administration resulted in normalization of tissue levels of both isoforms of vitamin D3 25-hydroxylase and blood serum 25OHD3 content. Diabetes-associated vitamin D3 deficiency correlated with a decrease in phagocytic activity of granulocytes and monocytes, and their ability to produce antibacterial biooxidants such as reactive oxygen and nitrogen forms. Vitamin D3 efficacy to attenuate these abnormalities of immune function was established, indicating an important immunoregulatory role of cholecalciferol in the phagocytic mechanism of antigens elimination implemented by granulocytes and monocytes.
Editor: Ukraine
Idioma: Ucraniano

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Vitamin D3 availability and functional activity of peripheral blood phagocytes in experimental type 1 diabetes

Labudzyns'kyĭ, D O ; Shymans'kyĭ, I O ; Riasnyĭ, V M ; Velykyĭ, M M

Ukraine

Buscando em bases de dados remotas. Favor aguardar.