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Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism

de Bem Alves, Ana Cristina ; Aguiar, Aderbal Silva

Purinergic signalling, 2024-02, Vol.20 (1), p.29-34 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism
Autor: de Bem Alves, Ana Cristina ; Aguiar, Aderbal Silva
Assuntos: Biomedical and Life Sciences ; Biomedicine ; Caffeine ; Cancer Research ; Dopamine D2 receptors ; Fatigue ; Haloperidol ; Human Physiology ; Levodopa ; Motor task performance ; Movement disorders ; Neostriatum ; Neurodegenerative diseases ; Neurosciences ; Neurotransmission ; Open-field behavior ; Original ; Original Article ; Parkinson's disease ; Pharmacology/Toxicology ; Reserpine ; Therapeutic targets
É parte de: Purinergic signalling, 2024-02, Vol.20 (1), p.29-34
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Fatigue is a non-motor symptom of Parkinson's disease (PD). Adenosine 2A receptor (A 2A R) and compromised dopamine neurotransmission are linked to fatigue. Studies demonstrate that A 2A R antagonism potentiates dopamine transmission via dopamine receptor D 2 (D 2 R). However, the heterodimer form of A 2A R-D 2 R in the striatum prompted questions about the therapeutic targets for PD patients. This study investigates the effects of caffeine (A 2A R non-selective antagonist) plus haloperidol (D 2 R selective antagonist) treatment in the fatigue induced by the reserpine model of PD. Reserpinized mice showed impaired motor control in the open field test ( p < 0.05) and fatigue in the grip strength meter test ( p < 0.05). L-DOPA and caffeine plus haloperidol similarly increased motor control ( p < 0.05) and mitigated fatigue ( p < 0.05). Our results support the A 2A R-D 2 R heterodimer participation in the central fatigue of PD, and highlight the potential of A 2A R-D 2 R antagonism in the management of PD.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

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Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism

de Bem Alves, Ana Cristina ; Aguiar, Aderbal Silva

Dordrecht: Springer Netherlands

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