skip to main content
Idioma:

Macroscopic and histopathological features of acute peritoneal infection in diabetic and euglycemic Wistar rats

Yakymenko, Oleksandr ; Suchok, Svitlana ; Lukiianets, Oleg ; Havryliuk, Andrii

Pediatric endocrinology, diabetes, and metabolism, 2022, Vol.28 (1), p.30-34 [Periódico revisado por pares]

Poland: Termedia Publishing House

Texto completo disponível

Citações Citado por
  • Título:
    Macroscopic and histopathological features of acute peritoneal infection in diabetic and euglycemic Wistar rats
  • Autor: Yakymenko, Oleksandr ; Suchok, Svitlana ; Lukiianets, Oleg ; Havryliuk, Andrii
  • Assuntos: Animals ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - pathology ; Humans ; Male ; Original paper | Praca oryginalna ; Peritoneum - pathology ; Peritonitis - etiology ; Peritonitis - pathology ; Rats ; Rats, Wistar
  • É parte de: Pediatric endocrinology, diabetes, and metabolism, 2022, Vol.28 (1), p.30-34
  • Descrição: Impact of the secondary peritoneal infections on the peritoneal morphology in diabetic population remains unclear. To study the histopathological changes of the peritoneum due to secondary bacterial peritonitis in diabetic rats in compari-son to the normoglycemic animals. 13 adult male Wistar rats were divided into 2 groups: control (n = 3) and experimental (n = 10). The latter was subdivided into non-diabetic (n = 5) and diabetic (n = 5). T1DM and peritonitis were induced through the single intraperitoneal injec-tion of Streptozotocin (60 mg/kg) and intraperitoneal injection of 2 ml of the faecal matter, respectively. Macroscopic findings of diabetic rat peritoneum included significant accumulation of the exudate in the peritoneal cavity and presence of intraintestinal adhesions and abscesses. Morphology of the peritonium presented with diffuse, profound degenerative and inflammatory lesions involving the subjacent tissues. In contrast, the underlying muscular layer of the non-diabetic rats remained intact. Natural course of the peritoneal infection in diabetic rats (48 hours) is characterised by diffuse severe peritonitis with inter-intestinal abscess formation and more profound subadjacent tissue involvement in comparison with non-diabetic rats.
  • Editor: Poland: Termedia Publishing House
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.