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Novel Biodegradable Laminarin Microparticles for Biomedical Applications

Castanheira, Edgar J ; Correia, Tiago R ; Rodrigues, João M M ; Mano, João F

Bulletin of the Chemical Society of Japan, 2020-06, Vol.93 (6), p.713-719 [Periódico revisado por pares]

Tokyo: The Chemical Society of Japan

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  • Título:
    Novel Biodegradable Laminarin Microparticles for Biomedical Applications
  • Autor: Castanheira, Edgar J ; Correia, Tiago R ; Rodrigues, João M M ; Mano, João F
  • Assuntos: Biocompatibility ; Biodegradability ; Biological activity ; Biological properties ; Biomedical materials ; Biopolymers ; Drug delivery systems ; Fluorescein ; Microparticles ; Polysaccharides ; Synthesis ; Toxicity
  • É parte de: Bulletin of the Chemical Society of Japan, 2020-06, Vol.93 (6), p.713-719
  • Descrição: Fabrication of biocompatible polymeric carriers for sustained/controlled drug-delivery have been extensively explored over the years. Furthermore, systems based on polymers from natural origins exceed conventional polymers in biocompatibility, biodegradability and cost efficiency. Polysaccharides are one of the most common biopolymers found in nature and they can achieve a high degree of complexity and fine biological properties. Herein, is proposed a biodegradable and biocompatible microcarrier synthesized from laminarin, a low Mw marine polysaccharide based on glucose units with great biological activity, such as immune modulation and antimicrobial properties. Within this work, controlled size microparticles were obtained from novel modifications of laminarin. Microparticles showed 40% release of fluorescein isothiocyanate-dextran (70 kDa) after 24 h and full degradability after 11 days, when in physiological conditions. When incubated with human adipose stem and L929 cell lines (up to a microparticle concentration of 100 µg/mL) no cytotoxicity was perceived, and neither membrane or nucleus disturbance. Thus, microparticles synthesized from laminarin, proved to be a cost efficient, biocompatible and biodegradable system.
  • Editor: Tokyo: The Chemical Society of Japan
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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