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CaM Kinase: Still Inspiring at 40

Bayer, K. Ulrich ; Schulman, Howard

Neuron (Cambridge, Mass.), 2019-08, Vol.103 (3), p.380-394 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
CaM Kinase: Still Inspiring at 40
Autor: Bayer, K. Ulrich ; Schulman, Howard
Assuntos: Amino Acid Sequence ; Animals ; Binding sites ; Brain - enzymology ; Ca2+/calmodulin-dependent protein kinase II ; Calcium-binding protein ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology ; Calmodulin ; CaMKII ; Cell cycle ; Cognition - physiology ; Communication ; DAPK ; Humans ; Kinases ; Long-term depression ; Long-term potentiation ; Long-Term Potentiation - physiology ; LTD ; LTP ; memory ; Memory - physiology ; Models, Molecular ; Multigene Family ; Nerve Tissue Proteins - chemistry ; Nerve Tissue Proteins - physiology ; Phosphorylation ; Protein Conformation ; Protein Domains ; Protein Interaction Mapping ; Protein Processing, Post-Translational ; Protein-Serine-Threonine Kinases - classification ; Protein-Serine-Threonine Kinases - physiology ; Proteins ; Receptors, N-Methyl-D-Aspartate - metabolism ; synapse ; Synaptic Transmission
É parte de: Neuron (Cambridge, Mass.), 2019-08, Vol.103 (3), p.380-394
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as a memory molecule, even before its involvement in long-term potentiation (LTP) was shown. The enzyme has not disappointed, with subsequent demonstrations of remarkable structural and regulatory properties. Its neuronal functions now extend to long-term depression (LTD), and last year saw the first direct evidence for memory storage by CaMKII. Although CaMKII may have taken the spotlight, it is a member of a large family of diverse and interesting CaM kinases. Our aim is to place CaMKII in context of the other CaM kinases and then review certain aspects of this kinase that are of current interest. Bayer and Schulman discuss CaMKII in the context of other CaM kinases, its complex regulation, and diverse neuronal functions, including as a central regulator of neuronal plasticity and learning.
Editor: United States: Elsevier Inc
Idioma: Inglês

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CaM Kinase: Still Inspiring at 40

Bayer, K. Ulrich ; Schulman, Howard

United States: Elsevier Inc

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