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Migraine and risk of cardiovascular diseases: Danish population based matched cohort study

Adelborg, Kasper ; Szépligeti, Szimonetta Komjáthiné ; Holland-Bill, Louise ; Ehrenstein, Vera ; Horváth-Puhó, Erzsébet ; Henderson, Victor W ; Sørensen, Henrik Toft

BMJ (Online), 2018-01, Vol.360, p.k96-k96 [Periódico revisado por pares]

England: BMJ Publishing Group LTD

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Título:
Migraine and risk of cardiovascular diseases: Danish population based matched cohort study
Autor: Adelborg, Kasper ; Szépligeti, Szimonetta Komjáthiné ; Holland-Bill, Louise ; Ehrenstein, Vera ; Horváth-Puhó, Erzsébet ; Henderson, Victor W ; Sørensen, Henrik Toft
Assuntos: Adult ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - etiology ; Body Mass Index ; Cardiac arrhythmia ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cerebral infarction ; Cohort analysis ; Cohort Studies ; Comorbidity ; Denmark - epidemiology ; Female ; Fibrillation ; Headache ; Health risk assessment ; Heart diseases ; Heart Failure - epidemiology ; Heart Failure - etiology ; Humans ; Incidence ; Intracranial Hemorrhages - epidemiology ; Intracranial Hemorrhages - etiology ; Male ; Middle Aged ; Migraine ; Migraine Disorders - complications ; Migraine Disorders - diagnosis ; Migraine Disorders - epidemiology ; Myocardial infarction ; Myocardial Infarction - epidemiology ; Myocardial Infarction - etiology ; Outcome Assessment, Health Care ; Peripheral Arterial Disease - epidemiology ; Peripheral Arterial Disease - etiology ; Population studies ; Population-based studies ; Prospective Studies ; Risk Factors ; Smoking ; Smoking - epidemiology ; Stroke - epidemiology ; Stroke - etiology ; Systematic review ; Thromboembolism ; Vascular diseases ; Venous Thromboembolism - epidemiology ; Venous Thromboembolism - etiology
É parte de: BMJ (Online), 2018-01, Vol.360, p.k96-k96
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: AbstractObjectiveTo examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort.DesignNationwide, population based cohort study.SettingAll Danish hospitals and hospital outpatient clinics from 1995 to 2013.Participants51 032 patients with migraine and 510 320 people from the general population matched on age, sex, and calendar year.Main outcome measuresComorbidity adjusted hazard ratios of cardiovascular outcomes based on Cox regression analysis.ResultsHigher absolute risks were observed among patients with incident migraine than in the general population across most outcomes and follow-up periods. After 19 years of follow-up, the cumulative incidences per 1000 people for the migraine cohort compared with the general population were 25 v 17 for myocardial infarction, 45 v 25 for ischaemic stroke, 11 v 6 for haemorrhagic stroke, 13 v 11 for peripheral artery disease, 27 v 18 for venous thromboembolism, 47 v 34 for atrial fibrillation or atrial flutter, and 19 v 18 for heart failure. Correspondingly, migraine was positively associated with myocardial infarction (adjusted hazard ratio 1.49, 95% confidence interval 1.36 to 1.64), ischaemic stroke (2.26, 2.11 to 2.41), and haemorrhagic stroke (1.94, 1.68 to 2.23), as well as venous thromboembolism (1.59, 1.45 to 1.74) and atrial fibrillation or atrial flutter (1.25, 1.16 to 1.36). No meaningful association was found with peripheral artery disease (adjusted hazard ratio 1.12, 0.96 to 1.30) or heart failure (1.04, 0.93 to 1.16). The associations, particularly for stroke outcomes, were stronger during the short term (0-1 years) after diagnosis than the long term (up to 19 years), in patients with aura than in those without aura, and in women than in men. In a subcohort of patients, the associations persisted after additional multivariable adjustment for body mass index and smoking.ConclusionsMigraine was associated with increased risks of myocardial infarction, ischaemic stroke, haemorrhagic stroke, venous thromboembolism, and atrial fibrillation or atrial flutter. Migraine may be an important risk factor for most cardiovascular diseases.
Editor: England: BMJ Publishing Group LTD
Idioma: Inglês

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Migraine and risk of cardiovascular diseases: Danish population based matched cohort study

Adelborg, Kasper ; Szépligeti, Szimonetta Komjáthiné ; Holland-Bill, Louise ; Ehrenstein, Vera ; Horváth-Puhó, Erzsébet ; Henderson, Victor W ; Sørensen, Henrik Toft

England: BMJ Publishing Group LTD

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