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Plasma and urine concentrations of atrial natriuretic peptide in patients with diabetes mellitus

SUZUKI, Y ; SUZUKI, H ; OHTAKE, R ; TSUCHIYA, T ; MURAMATSU, H ; HASHIGAMI, Y ; KOBORI, H ; SHIMODA, S.-I

Pancreas, 1988, Vol.3 (4), p.404-408 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Plasma and urine concentrations of atrial natriuretic peptide in patients with diabetes mellitus
Autor: SUZUKI, Y ; SUZUKI, H ; OHTAKE, R ; TSUCHIYA, T ; MURAMATSU, H ; HASHIGAMI, Y ; KOBORI, H ; SHIMODA, S.-I
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Atrial Natriuretic Factor - blood ; Atrial Natriuretic Factor - metabolism ; Atrial Natriuretic Factor - urine ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Diabetes Mellitus - blood ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - urine ; Endocrinopathies ; Female ; Humans ; Kidney Function Tests ; Male ; Medical sciences ; Middle Aged ; Radioimmunoassay
É parte de: Pancreas, 1988, Vol.3 (4), p.404-408
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: To examine whether plasma and urine concentrations of human atrial natriuretic peptide (hANP) are altered in patients with diabetes mellitus (DM), plasma and urine hANP concentrations were evaluated in 86 patients with diabetes mellitus using an extraction procedure. The mean recovery rate of extraction was 71.8 +/- 0.6% (mean +/- SEM). The major immunoreactive component of hANP in extracted plasma and urine appeared to be identical to synthetic alpha hANP as judged by reverse-phase high-performance liquid chromatography (HPLC). The patients were divided into three groups according to their renal complications. The patients in group 1 had no apparent abnormality in serum creatinine, serum or urine beta 2-microglobulin (beta 2-MG), or urine N-acetyl-beta-D-glucosaminidase (NAG); those in group 2 showed either beta 2-MG or NAG abnormality but no creatinine abnormality. The patients in group 3 were though to have an established diabetic nephropathy and showed a serum creatinine increase. Plasma ANP concentrations in groups 1, 2, and 3 were 10.7 +/- 2.1, 19.9 +/- 5.6, and 39.2 +/- 9.9 fmol/ml, respectively. These values in groups 2 and 3 were significantly higher than the control values (p less than 0.05 or p less than 0.01 versus 6.2 +/- 0.7 fmol/ml). Urine ANP concentrations in group 1 were also within normal range, though those in groups 2 and 3 markedly increased in comparison with normal values.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Plasma and urine concentrations of atrial natriuretic peptide in patients with diabetes mellitus

SUZUKI, Y ; SUZUKI, H ; OHTAKE, R ; TSUCHIYA, T ; MURAMATSU, H ; HASHIGAMI, Y ; KOBORI, H ; SHIMODA, S.-I

Hagerstown, MD: Lippincott Williams & Wilkins

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