Idioma:

Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women

Coelho, F.M ; Pereira, D.S ; Lustosa, L.P ; Silva, J.P ; Dias, J.M.D ; Dias, R.C.D ; Queiroz, B.Z ; Teixeira, A.L ; Teixeira, M.M ; Pereira, L.S.M

Archives of gerontology and geriatrics, 2012-05, Vol.54 (3), p.415-420 [Periódico revisado por pares]

Netherlands: Elsevier Ireland Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women
Autor: Coelho, F.M ; Pereira, D.S ; Lustosa, L.P ; Silva, J.P ; Dias, J.M.D ; Dias, R.C.D ; Queiroz, B.Z ; Teixeira, A.L ; Teixeira, M.M ; Pereira, L.S.M
Assuntos: Aged ; Biological markers ; biomarkers ; Body weight ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Central nervous system diseases ; Elderly people ; Elderly women ; Enzyme-linked immunosorbent assay ; Female ; Frail ; Frail Elderly ; Frailty ; Geriatrics ; Glial cell line-derived neurotrophic factor ; Glial Cell Line-Derived Neurotrophic Factor - blood ; Hand Injuries - pathology ; Humans ; Internal Medicine ; Middle Aged ; Nerve growth factor ; Nerve Growth Factor - blood ; Nervous system ; Neuronal-glial interactions ; Neuroprotection ; Neurotrophic factors ; Phenotypes ; Physical therapy intervention ; Physical Therapy Modalities ; Resistance Training - methods ; Risk factors
É parte de: Archives of gerontology and geriatrics, 2012-05, Vol.54 (3), p.415-420
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
ObjectType-Feature-1
ObjectType-Article-1
ObjectType-Feature-2
Descrição: Abstract Biomarkers are important factors in the identification of the frail elderly (higher risk of developing disease) and in assessing the impact of PTI. On the other hand, BDNF has been related to neuroprotection in a series of central nervous system diseases in older age. The levels of BDNF in groups of elderly women classified according to Fried phenotype (non-frail and pre-frail) were compared. We assessed the impact of a PTI on BDNF levels. A convenience sample of 48 elderly women was randomly selected. The PTI group was composed by 20 elderly women selected from this group. Plasma neurotrophic factors, such as BDNF, glial-derived neutrophic factor (GDNF), and nerve growth factor (NGF) were measured by enzyme-linked immunosorbent assay (ELISA). Timed-up-and-go (TUG) test, hand-grip and work/body weight were evaluated before and after the intervention. Plasma concentrations of BDNF were significantly higher in non-frail in comparison to pre-frail elderly women. After the PTI, higher levels of BDNF were found in elderly women (before 351 ± 68 pg/ml and after 593 ± 79 pg/ml; p < 0.001). Both groups had an increase in BDNF levels after the PTI. The low levels of BDNF in pre-frail elderly women suggest that this neurotrophic factor may be a key pathophysiological mediator in the syndrome of frailty. The fact that PTI increased BDNF levels in both groups suggests that it may be possible to modify this phenotype.
Editor: Netherlands: Elsevier Ireland Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 8 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women

Coelho, F.M ; Pereira, D.S ; Lustosa, L.P ; Silva, J.P ; Dias, J.M.D ; Dias, R.C.D ; Queiroz, B.Z ; Teixeira, A.L ; Teixeira, M.M ; Pereira, L.S.M

Netherlands: Elsevier Ireland Ltd

Buscando em bases de dados remotas. Favor aguardar.