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The human spleen is a major reservoir for long-lived vaccinia virus–specific memory B cells

Mamani-Matsuda, Maria ; Cosma, Antonio ; Weller, Sandra ; Faili, Ahmad ; Staib, Caroline ; Garçon, Loïc ; Hermine, Olivier ; Beyne-Rauzy, Odile ; Fieschi, Claire ; Pers, Jacques-Olivier ; Arakelyan, Nina ; Varet, Bruno ; Sauvanet, Alain ; Berger, Anne ; Paye, François ; Andrieu, Jean-Marie ; Michel, Marc ; Godeau, Bertrand ; Buffet, Pierre ; Reynaud, Claude-Agnès ; Weill, Jean-Claude

Blood, 2008-05, Vol.111 (9), p.4653-4659 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
The human spleen is a major reservoir for long-lived vaccinia virus–specific memory B cells
Autor: Mamani-Matsuda, Maria ; Cosma, Antonio ; Weller, Sandra ; Faili, Ahmad ; Staib, Caroline ; Garçon, Loïc ; Hermine, Olivier ; Beyne-Rauzy, Odile ; Fieschi, Claire ; Pers, Jacques-Olivier ; Arakelyan, Nina ; Varet, Bruno ; Sauvanet, Alain ; Berger, Anne ; Paye, François ; Andrieu, Jean-Marie ; Michel, Marc ; Godeau, Bertrand ; Buffet, Pierre ; Reynaud, Claude-Agnès ; Weill, Jean-Claude
Assuntos: B-Lymphocytes - immunology ; B-Lymphocytes - virology ; Biological and medical sciences ; Case-Control Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoglobulin G ; Immunologic Memory ; Microbiology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Spleen - cytology ; Spleen - immunology ; Splenectomy ; Vaccinia virus - immunology ; Virology
É parte de: Blood, 2008-05, Vol.111 (9), p.4653-4659
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We report that, whereas blood and spleen compartments present similar frequencies of IgG+ cells, antismallpox memory B cells are specifically enriched in the spleen where they account for 0.24% of all IgG+ cells (ie, 10-20 million cells) more than 30 years after vaccination. They represent, in contrast, only 0.07% of circulating IgG+ B cells in blood (ie, 50-100 000 cells). An analysis of patients either splenectomized or rituximab-treated confirmed that the spleen is a major reservoir for long-lived memory B cells. No significant correlation was observed between the abundance of these cells in blood and serum titers of antivaccinia virus antibodies in this study, including in the contrasted cases of B cell– depleting treatments. Altogether, these data provide evidence that in humans, the two arms of B-cell memory—long-lived memory B cells and plasma cells—have specific anatomic distributions—spleen and bone marrow—and homeostatic regulation.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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The human spleen is a major reservoir for long-lived vaccinia virus–specific memory B cells

Washington, DC: Elsevier Inc

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