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Antiepileptic drugs patterns in elderly inpatients in a Brazilian tertiary center, Salvador, Brazil

Assis, Telma Rocha de ; Nascimento, Osvaldo J M ; Costa, Gersonita ; Bacellar, Aroldo

Arquivos de neuro-psiquiatria, 2014-11, Vol.72 (11), p.874-880 [Peer Reviewed Journal]

Brazil: Academia Brasileira de Neurologia - ABNEURO

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Title:
Antiepileptic drugs patterns in elderly inpatients in a Brazilian tertiary center, Salvador, Brazil
Author: Assis, Telma Rocha de ; Nascimento, Osvaldo J M ; Costa, Gersonita ; Bacellar, Aroldo
Subjects: Aged ; Aged, 80 and over ; Anticonvulsants - therapeutic use ; Brazil ; Comorbidity ; crises epilépticas ; Cross-Sectional Studies ; drogas antiepilépticas ; epilepsia ; Epilepsy - drug therapy ; Female ; Hospitalization ; Humans ; idosos ; Inappropriate Prescribing - statistics & numerical data ; Male ; Middle Aged ; NEUROSCIENCES ; PSYCHIATRY ; Retrospective Studies ; Risk Factors ; Seizures - drug therapy ; Tertiary Care Centers - statistics & numerical data
Is Part Of: Arquivos de neuro-psiquiatria, 2014-11, Vol.72 (11), p.874-880
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Epilepsy is very prevalent among elderly inpatients and treatment is far from ideal. To analyze prescribing patterns of antiepileptic drugs (AEDs) for hospitalized elderly with epilepsy, their relations with comorbidities and comedications. We assessed prescription regimen of elderly patients that were under AED use for treatment of epileptic seizures, during hospitalization. One hundred and nine patients were enrolled. AED regimen was categorized into two groups: Group 1 defined as appropriate (carbamazepine, oxcarbazepine, valproic acid, gabapentin, clobazan and lamotrigine) and Group 2 as inappropriate (phenytoin and phenobarbital). We found 73.4% of patients used inappropriate AEDs (p<0.001). Monotherapy was prescribed for 71.6% of patients. The most common comorbidity was hypertension. Potentially proconvulsant drugs as comedications were used for nearly half of patients. Inappropriate AED therapy was commonly prescribed regimen for elderly inpatients. Some recommendations are discussed for a better care of elderly inpatients with epilepsy.
Publisher: Brazil: Academia Brasileira de Neurologia - ABNEURO
Language: English;Portuguese

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Antiepileptic drugs patterns in elderly inpatients in a Brazilian tertiary center, Salvador, Brazil

Assis, Telma Rocha de ; Nascimento, Osvaldo J M ; Costa, Gersonita ; Bacellar, Aroldo

Brazil: Academia Brasileira de Neurologia - ABNEURO

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