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Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats

dos Santos, Vinicius Ruan Neves ; Motta, João Victor da Silva ; Frazão, Deborah Ribeiro ; Ferreira, Railson de Oliveira ; Souza-Monteiro, Deiweson ; Baia-da-Silva, Daiane Claydes ; Mendes, Paulo Fernando Santos ; Bittencourt, Leonardo Oliveira ; de Moura, João Daniel Mendonça ; Lameira, Osmar Alves ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Rösing, Cassiano Kuchenbecker ; Lima, Rafael Rodrigues

Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6255 [Periódico revisado por pares]

Basel: MDPI AG

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Título:
Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats
Autor: dos Santos, Vinicius Ruan Neves ; Motta, João Victor da Silva ; Frazão, Deborah Ribeiro ; Ferreira, Railson de Oliveira ; Souza-Monteiro, Deiweson ; Baia-da-Silva, Daiane Claydes ; Mendes, Paulo Fernando Santos ; Bittencourt, Leonardo Oliveira ; de Moura, João Daniel Mendonça ; Lameira, Osmar Alves ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Rösing, Cassiano Kuchenbecker ; Lima, Rafael Rodrigues
Assuntos: Alveolar bone ; alveolar bone loss ; Amazonian biodiversity ; Animals ; Biofilms ; Biological activity ; Bone loss ; Cancellous bone ; complementary therapies ; Computed tomography ; copaiba oleoresin ; Copaifera officinalis ; Copaifera reticulata Ducke ; Gum disease ; Homeopathy ; Inflammation ; Investigations ; Materia medica and therapeutics ; Medical treatment ; micro-CT ; Natural products ; Oleoresins ; Pathogenesis ; Pathogens ; Pathophysiology ; Periodontitis ; Therapeutics
É parte de: Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6255
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These authors contributed equally to this work.
Descrição: Several studies have investigated the effects of natural products in the treatment of diseases. Traditional Amazonian populations commonly use copaiba due to its well-known anti-inflammatory, antibacterial, and healing properties. In this study, we aimed to investigate the effects of systemic administration of copaiba oleoresin (Copaifera reticulata Ducke) on ligature-induced periodontitis in rats. To do so, 21 adult rats were divided into three groups (n = 7 each): a control group, ligature-induced periodontitis group, and ligature-induced periodontitis group treated with copaiba oleoresin (200 mg/kg/day). The ligature remained from day 0 to 14, and the copaiba oleoresin was administered via oral gavage during the last seven days. On day 14, the animals were euthanized, and mandibles were collected for histopathological evaluation and microcomputed tomography analysis. Our data showed that the administration of copaiba considerably reduced the inflammatory profile. Moreover, copaiba oleoresin limited alveolar bone loss, increased trabecular thickness and bone-to-tissue volume ratio, and decreased the number of trabeculae compared with those of the untreated experimental periodontitis group. Our findings provide pioneering evidence that supports the potential of copaiba oleoresin in reducing periodontitis-induced alveolar bone damage in rats.
Editor: Basel: MDPI AG
Idioma: Inglês

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Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats

Basel: MDPI AG

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