Language:

Mechanistic basis of infertility of mouse intersubspecific hybrids

Bhattacharyya, Tanmoy ; Gregorova, Sona ; Mihola, Ondrej ; Anger, Martin ; Sebestova, Jaroslava ; Denny, Paul ; Simecek, Petr ; Forejt, Jiri

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.E468-E477 [Peer Reviewed Journal]

United States: National Academy of Sciences

Full text available

Citations Cited by

Actions
1. Add to e-Shelf
2. Remove from e-Shelf
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Mechanistic basis of infertility of mouse intersubspecific hybrids
Author: Bhattacharyya, Tanmoy ; Gregorova, Sona ; Mihola, Ondrej ; Anger, Martin ; Sebestova, Jaroslava ; Denny, Paul ; Simecek, Petr ; Forejt, Jiri
Subjects: Animal reproduction ; Animals ; Apoptosis - genetics ; Biological Evolution ; Biological Sciences ; Cell division ; Chromosome Pairing - genetics ; Chromosomes ; Crosses, Genetic ; DNA Breaks, Double-Stranded ; Female ; Genetic Speciation ; Genomes ; Infertility ; Infertility - genetics ; Infertility - pathology ; Infertility - physiopathology ; Male ; Meiosis - genetics ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred Strains - classification ; Mice, Inbred Strains - genetics ; Mice, Inbred Strains - physiology ; Models, Biological ; Oocytes - pathology ; PNAS Plus ; Pregnancy ; Recombination, Genetic ; Rodents ; Species Specificity ; Spermatocytes - pathology ; Spermatogenesis - genetics ; Transcriptome
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.E468-E477
Notes: http://dx.doi.org/10.1073/pnas.1219126110
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by R. Scott Hawley, Stowers Institute for Medical Research, Kansas City, MO, and approved December 19, 2012 (received for review November 5, 2012)
Author contributions: J.F. designed research; T.B., S.G., O.M., M.A., J.S., and P.S. performed research; T.B., M.A., P.D., P.S., and J.F. analyzed data; and T.B., M.A., and J.F. wrote the paper.
Description: According to the Dobzhansky–Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unless a particular gene or nongenic sequence diverges much faster than the rest of the genome. Here we propose that asynapsis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger for the meiotic arrest of interspecific F1 hybrids. We observed extensive asynapsis of chromosomes and disturbance of the sex body in >95% of pachynemas of Mus m. musculus × Mus m. domesticus sterile F1 males. Asynapsis was not preceded by a failure of double-strand break induction, and the rate of meiotic crossing over was not affected in synapsed chromosomes. DNA double-strand break repair was delayed or failed in unsynapsed autosomes, and misexpression of chromosome X and chromosome Y genes was detected in single pachynemas and by genome-wide expression profiling. Oocytes of F1 hybrid females showed the same kind of synaptic problems but with the incidence reduced to half. Most of the oocytes with pachytene asynapsis were eliminated before birth. We propose the heterospecific pairing of homologous chromosomes as a preexisting condition of asynapsis in interspecific hybrids. The asynapsis may represent a universal mechanistic basis of F1 hybrid sterility manifested by pachytene arrest. It is tempting to speculate that a fast-evolving subset of the noncoding genomic sequence important for chromosome pairing and synapsis may be the culprit.
Publisher: United States: National Academy of Sciences
Language: English

Links

View this record in MEDLINE/PubMed

Back to results list

Previous Result 5 Next Go to Next page

Implemented by: Social Network Logos:

Mechanistic basis of infertility of mouse intersubspecific hybrids

Bhattacharyya, Tanmoy ; Gregorova, Sona ; Mihola, Ondrej ; Anger, Martin ; Sebestova, Jaroslava ; Denny, Paul ; Simecek, Petr ; Forejt, Jiri

United States: National Academy of Sciences

Searching Remote Databases, Please Wait