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Case-Control Study of Diabetes, Obesity, Physical Activity and Risk of Endometrial Cancer among Mexican Women

Salazar-Martínez, Eduardo ; Lazcano-Ponce, Eduardo Cesar ; Lira-Lira, Guillermo González ; Pedro Escudero-De los Ríos ; Salmerón-Castro, Jorge ; Larrea, Fernando ; Hernández-Avila, Mauricio

Cancer causes & control, 2000-09, Vol.11 (8), p.707-711 [Periódico revisado por pares]

Netherlands: Kluwer Academic Publishers

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Título:
Case-Control Study of Diabetes, Obesity, Physical Activity and Risk of Endometrial Cancer among Mexican Women
Autor: Salazar-Martínez, Eduardo ; Lazcano-Ponce, Eduardo Cesar ; Lira-Lira, Guillermo González ; Pedro Escudero-De los Ríos ; Salmerón-Castro, Jorge ; Larrea, Fernando ; Hernández-Avila, Mauricio
Assuntos: Adult ; Aged ; Body mass index ; Case control studies ; Diabetes ; Diabetes Complications ; Diabetes mellitus ; Endometrial Neoplasms - epidemiology ; Endometrial Neoplasms - etiology ; Exercise ; Female ; Humans ; Hypertension ; Mexico ; Middle Aged ; Obesity ; Obesity - complications ; Overweight ; Research Papers ; Risk Factors ; Type 2 diabetes mellitus
É parte de: Cancer causes & control, 2000-09, Vol.11 (8), p.707-711
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Objectives: Obesity, hypertension and diabetes are closely associated with endometrial cancer (EC). This study evaluates the relationship between diabetes and risk of EC on the basis of obesity. Methods: A case-control study was carried out in Mexico City from 1995 to 1997. Eighty-five histologically confirmed cases were compared with 668 population-based controls obtained through frequency matching. Diabetes status, weight, height and other factors were determined through personal interviews among both cases and controls. Results: Compared to women without diabetes, those with diabetes had an adjusted odds ratio of 3.6 (95% CI = 1.7, 7.4) for EC. This association was modified by body mass index (p interaction < 0.001). Compared to non-overweight and non-diabetic women, non-overweight (OR = 3.9, 95% CI = 0.88, 18.0) and overweight (OR = 5.9, 95% CI = 1.6, 21.1) diabetic women had a non-significant elevated risk of EC. However, elevated risk estimates were observed for obese diabetic women (OR = 8.0, 95% CI = 2.8, 22.7). Conclusions: Our results strongly suggest an interaction effect between obesity and diabetes that significantly increases the risk of EC. This, in turn, may explain the growing number of new EC cases recently observed in developing countries with reduced birth rates and an increased incidence of both obesity and diabetes mellitus.
Editor: Netherlands: Kluwer Academic Publishers
Idioma: Inglês

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Case-Control Study of Diabetes, Obesity, Physical Activity and Risk of Endometrial Cancer among Mexican Women

Salazar-Martínez, Eduardo ; Lazcano-Ponce, Eduardo Cesar ; Lira-Lira, Guillermo González ; Pedro Escudero-De los Ríos ; Salmerón-Castro, Jorge ; Larrea, Fernando ; Hernández-Avila, Mauricio

Netherlands: Kluwer Academic Publishers

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