Developmental and Early Life Origins of Cardiometabolic Risk Factors: Novel Findings and Implications
ABCD PBi
Developmental and Early Life Origins of Cardiometabolic Risk Factors: Novel Findings and Implications
Autor:
Lurbe, Empar
;
Ingelfinger, Julie
Assuntos:
Adolescent
;
Adult
;
Adverse Childhood Experiences
;
Aging
;
Birth Weight
;
Cardiovascular Diseases - embryology
;
Cardiovascular Diseases - etiology
;
Cardiovascular System - growth & development
;
Child
;
Child, Preschool
;
Epigenesis, Genetic
;
Epigenomics - methods
;
Female
;
Forecasting
;
Gestational Age
;
Humans
;
Infant
;
Infant
, Low Birth Weight
;
Infant
, Newborn
;
Infant
, Premature
;
Male
;
Metabolic Diseases - embryology
;
Metabolic Diseases - etiology
;
Metabolomics
;
Microbiota
;
Middle Aged
;
Precision Medicine
;
Pregnancy
;
Prenatal Exposure Delayed Effects
;
Proteomics
;
Risk Factors
É parte de:
Hypertension (Dallas, Tex. 1979), 2021-02, Vol.77 (2), p.308-318
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
The intent of this review is to critically consider the data that support the concept of programming and its implications. Birth weight and growth trajectories during childhood are associated with cardiometabolic disease in adult life. Both extremes, low and high birth weight coupled with postnatal growth increase the early presence of cardiometabolic risk factors and vascular imprinting, crucial elements of this framework. Data coming from epigenetics, proteomics, metabolomics, and microbiota added relevant information and contribute to better understanding of mechanisms as well as development of biomarkers helping to move forward to take actions. Research has reached a stage in which sufficiently robust data calls for new initiatives focused on early life. Prevention starting early in life is likely to have a very large impact on reducing disease incidence and its associated effects at the personal, economic, and social levels.
Editor:
United States
Idioma:
Inglês