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Transmembrane protein 25 abrogates monomeric EGFR‐driven STAT3 activation in triple‐negative breast cancer

Mohan, Chakrabhavi Dhananjaya ; Rangappa, Kanchugarakoppal S. ; Sethi, Gautam

MedComm (2020), 2024-04, Vol.5 (4), p.e492-n/a [Periódico revisado por pares]

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Título:
Transmembrane protein 25 abrogates monomeric EGFR‐driven STAT3 activation in triple‐negative breast cancer
Autor: Mohan, Chakrabhavi Dhananjaya ; Rangappa, Kanchugarakoppal S. ; Sethi, Gautam
Assuntos: Highlights
É parte de: MedComm (2020), 2024-04, Vol.5 (4), p.e492-n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In wild‐type cells, TMEM25 physically associates with EGFR monomer and suppresses the EGFR‐mediated STAT3 phosphorylation, which results in the sequestration of unphosphorylated STAT3 in the cytoplasm. In TMEM‐/‐ cells, EGFR monomer phosphorylates STAT3 at the basal level.
Editor: China: John Wiley & Sons, Inc
Idioma: Inglês;Italiano

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