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Human Adenovirus Ad-36 Promotes Weight Gain in Male Rhesus and Marmoset Monkeys

Dhurandhar, Nikhil V. ; Whigham, Leah D. ; Abbott, David H. ; Schultz-Darken, Nancy J. ; Israel, Barbara A. ; Bradley, Steven M. ; Kemnitz, Joseph W. ; Allison, David B. ; Atkinson, Richard L.

The Journal of nutrition, 2002-10, Vol.132 (10), p.3155-3160 [Periódico revisado por pares]

Bethesda, MD: Elsevier Inc

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Título:
Human Adenovirus Ad-36 Promotes Weight Gain in Male Rhesus and Marmoset Monkeys
Autor: Dhurandhar, Nikhil V. ; Whigham, Leah D. ; Abbott, David H. ; Schultz-Darken, Nancy J. ; Israel, Barbara A. ; Bradley, Steven M. ; Kemnitz, Joseph W. ; Allison, David B. ; Atkinson, Richard L.
Assuntos: Adenoviridae Infections - complications ; Adenoviruses, Human - immunology ; Adenoviruses, Human - pathogenicity ; Adipose Tissue - virology ; adiposity ; Animals ; Antibodies, Viral - blood ; Biological and medical sciences ; Callitrichinae ; cholesterol ; Cholesterol - blood ; Disease Models, Animal ; Experimental viral diseases and models ; Humans ; infection ; Infectious diseases ; Macaca mulatta ; Male ; Medical sciences ; Metabolic diseases ; Monkeys & apes ; nonhuman primates ; Obesity ; Obesity - etiology ; Obesity - immunology ; Obesity - virology ; Physical growth ; Random Allocation ; Viral diseases ; Viruses ; Weight Gain
É parte de: The Journal of nutrition, 2002-10, Vol.132 (10), p.3155-3160
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Although obesity has multiple etiologies, an overlooked possibility is an infectious origin. We previously identified two viruses, SMAM-1, an avian adenovirus (Ad), and Ad-36, a human adenovirus, that produce a syndrome of visceral obesity, with paradoxically decreased serum cholesterol and triglycerides in chickens and mice. In the two studies presented in this paper, we used nonhuman primates to investigate the adiposity-promoting potential of Ad-36. In study 1, we observed spontaneously occurring Ad-36 antibodies in 15 male rhesus monkeys, and a significant longitudinal association of positive antibody status with weight gain and plasma cholesterol lowering during the 18 mo after viral antibody appearance. In study 2, which was a randomized controlled experiment, three male marmosets inoculated with Ad-36 had a threefold body weight gain, a greater fat gain and lower serum cholesterol relative to baseline (P <0.05) than three uninfected controls at 28 wk postinoculation. These studies illustrate that the adiposity-promoting effect of Ad-36 occurs in two nonhuman primate species and demonstrates the usefulness of nonhuman primates for further evaluation of Ad-36–induced adiposity.
Editor: Bethesda, MD: Elsevier Inc
Idioma: Inglês

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Human Adenovirus Ad-36 Promotes Weight Gain in Male Rhesus and Marmoset Monkeys

Dhurandhar, Nikhil V. ; Whigham, Leah D. ; Abbott, David H. ; Schultz-Darken, Nancy J. ; Israel, Barbara A. ; Bradley, Steven M. ; Kemnitz, Joseph W. ; Allison, David B. ; Atkinson, Richard L.

Bethesda, MD: Elsevier Inc

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