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The role of polymorphonuclear leukocytes in the resistance to cutaneous Leishmaniasis

Lima, Glória M.A.C ; Vallochi, Adriana L ; Silva, Ulisses R ; Bevilacqua, Estela M.A.F ; Kiffer, Maı́sa M.F ; Abrahamsohn, Ises A

Immunology letters, 1998-12, Vol.64 (2), p.145-151 [Peer Reviewed Journal]

Netherlands: Elsevier B.V

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Title:
The role of polymorphonuclear leukocytes in the resistance to cutaneous Leishmaniasis
Author: Lima, Glória M.A.C ; Vallochi, Adriana L ; Silva, Ulisses R ; Bevilacqua, Estela M.A.F ; Kiffer, Maı́sa M.F ; Abrahamsohn, Ises A
Subjects: Animals ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - immunology ; Foot - parasitology ; Granulocyte depletion ; Granulocytes - immunology ; Leishmania major ; Leishmania major - immunology ; Leishmania major - isolation & purification ; Leishmaniasis, Cutaneous - immunology ; Leishmaniasis, Cutaneous - parasitology ; Leishmaniasis, Cutaneous - pathology ; Leukocyte Count ; Lymph Nodes - parasitology ; mAb RB6-8C5 ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neutrophils ; Neutrophils - immunology ; Neutrophils - parasitology ; Resistance
Is Part Of: Immunology letters, 1998-12, Vol.64 (2), p.145-151
Notes: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Description: The massive infiltration by polymorphonuclear leukocytes (PMN) soon after skin infection with Leishmania major suggests that PMN could participate in reducing parasite load and controlling the spreading of leishmanial infection. Yet, direct evidence for the participation of PMN in host defense against L. major was lacking. We investigated L. major infection in susceptible and resistant mice treated with the monoclonal (mAb) antibody RB6-8C5 that depletes the population of mature neutrophils and eosinophils. Both BALB/c and C57BL/6 mice depleted of PMN show accelerated parasite spreading and more severe footpad swelling than similarly infected untreated mice. In addition, significant higher parasite numbers were found in the lesion draining lymph nodes from PMN-depleted C57BL/6 mice. Histopathological analysis of the paw confirmed neutrophils containing ingested parasites as the dominant cell type in the infiltrate of the first days after infection and the nearly absolute neutrophil depletion in mAb-treated mice. Our data show the importance of PMN in early control of parasite load and parasitism spreading in cutaneous leishmaniasis.
Publisher: Netherlands: Elsevier B.V
Language: English

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The role of polymorphonuclear leukocytes in the resistance to cutaneous Leishmaniasis

Lima, Glória M.A.C ; Vallochi, Adriana L ; Silva, Ulisses R ; Bevilacqua, Estela M.A.F ; Kiffer, Maı́sa M.F ; Abrahamsohn, Ises A

Netherlands: Elsevier B.V

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