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Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Nakashima, Kinichi ; Narazaki, Masashi ; Taga, Tetsuya

FEBS letters, 1997-01, Vol.401 (1), p.49-52 [Periódico revisado por pares]

England: Elsevier B.V

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Título:
Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130
Autor: Nakashima, Kinichi ; Narazaki, Masashi ; Taga, Tetsuya
Assuntos: Antigens, CD - metabolism ; Carrier Proteins - metabolism ; Cytokine Receptor gp130 ; diabetes mutant ; Enzyme Activation ; extracellular signal-regulated protein kinases 2 ; gp130 ; Humans ; IL-6 ; interleukin-6 ; Leptin ; Membrane Glycoproteins - metabolism ; OB-R ; obese receptor ; p42 ERK2 ; p42ERK2 ; Phosphorylation ; Protein Kinases - metabolism ; Receptors, Cell Surface ; Receptors, Cytokine - metabolism ; Receptors, Leptin ; Recombinant Proteins - metabolism ; SHP-2 ; signal transducer and activator of transcription ; Signal Transduction ; Src homology domain 2 containing protein tyrosine phosphatase 2 ; STAT ; STAT3 ; Tyrosine - metabolism
É parte de: FEBS letters, 1997-01, Vol.401 (1), p.49-52
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The structure of leptin receptor (OB-R) is highly homologous to that of gp130, the common signal transducing receptor component for the interleukin-6 family of cytokines. Based on this structural similarity, we examined signaling processes initiated by OB-R in comparison with those by gp130. Stimulation of either a long form of OB-R or gp130 led to tyrosine phosphorylation of STAT3, whereas stimulation of the truncated form of OB-R that is predominantly expressed in db/ db mice failed to do so. Stimulation of the long form OB-R did not induce tyrosine phosphorylation of a Src homology domain 2 containing protein tyrosine phosphatase, SHP-2, while stimulation of gp130 did. In contrast, activation of p42 ERK2 is mediated by either the long form OB-R or gp130. Two closely related molecules, OB-R and gp130, thus appear to mediate overlapping but distinct signaling procedures.
Editor: England: Elsevier B.V
Idioma: Inglês

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Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Nakashima, Kinichi ; Narazaki, Masashi ; Taga, Tetsuya

England: Elsevier B.V

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