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The rapid induction of liver glycerophosphate acyltransferase in mice by clofibrate, a hypolipidemic agent

Das, A K ; Aquilina, J W ; Hajra, A K

The Journal of biological chemistry, 1983-03, Vol.258 (5), p.3090-3093 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The rapid induction of liver glycerophosphate acyltransferase in mice by clofibrate, a hypolipidemic agent
Autor: Das, A K ; Aquilina, J W ; Hajra, A K
Assuntos: Acyltransferases - genetics ; Animals ; Anticholesteremic Agents - pharmacology ; Clofibrate - pharmacology ; Enzyme Induction ; Glycerol-3-Phosphate O-Acyltransferase - genetics ; Liver - drug effects ; Liver - enzymology ; Male ; Mice ; Mice, Inbred ICR ; Microsomes, Liver - drug effects ; Microsomes, Liver - enzymology
É parte de: The Journal of biological chemistry, 1983-03, Vol.258 (5), p.3090-3093
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
Descrição: Administration of clofibrate to adult mice (20-25 mg of clofibrate/day) increased liver glycerophosphate acyltransferase (EC 2.3.1.15) activity by 2.3-fold within 24 h. This increased glycerophosphate acyltransferase activity was mainly localized in the liver microsomal fraction. Three other hypolipidemic drugs, i.e. Bezafibrate (Boehringer Mannheim Co.), Gemfibrozil (Warner-Lambert Co.) and Wy-14,643 (Wyeth Laboratories), when fed to mice, also increased the liver glycerophosphate acyltransferase activity by 2-3-fold in 24 h. Simultaneous administration of inhibitors of protein biosynthesis, such as cycloheximide or actinomycin D completely abolished such stimulation of liver glycerophosphate acyltransferase by clofibrate.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The rapid induction of liver glycerophosphate acyltransferase in mice by clofibrate, a hypolipidemic agent

Das, A K ; Aquilina, J W ; Hajra, A K

United States: Elsevier Inc

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