Idioma:

Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction

Campos-Staffico, Alessandra M ; Costa, Ana Paula R ; Carvalho, Luiz Sérgio F ; Moura, Filipe A ; Santos, Simone N ; Coelho-Filho, Otavio R ; Nadruz, Jr, Wilson ; Quinaglia E Silva, José C ; Sposito, Andrei C

Nutrition journal, 2019-05, Vol.18 (1), p.29-29, Article 29 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction
Autor: Campos-Staffico, Alessandra M ; Costa, Ana Paula R ; Carvalho, Luiz Sérgio F ; Moura, Filipe A ; Santos, Simone N ; Coelho-Filho, Otavio R ; Nadruz, Jr, Wilson ; Quinaglia E Silva, José C ; Sposito, Andrei C
Assuntos: Apoptosis ; Biomarkers - blood ; Blood pressure ; Brain natriuretic peptide ; Brazil ; C-reactive protein ; Cardiac remodeling ; Cardiovascular diseases ; Care and treatment ; Cholesterol ; Cohort Studies ; Complications and side effects ; Cytokines ; Diabetes ; Echocardiography ; Echocardiography, Three-Dimensional - methods ; Fatty acids ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - pharmacology ; Female ; Follow-Up Studies ; Health aspects ; Heart ; Heart attack ; Heart attacks ; Heart diseases ; Heart Ventricles - diagnostic imaging ; Humans ; Hypertension ; Inflammation ; Inflammation - blood ; Inflammation - etiology ; Inflammatory response ; Interleukin 2 ; Internet ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Mortality ; Myocardial infarction ; Neuroimaging ; Omega-3 ; Omega-3 fatty acids ; Physiological aspects ; Polyunsaturated fatty acids ; Prospective Studies ; Proteins ; Questionnaires ; Risk factors ; ST Elevation Myocardial Infarction - blood ; ST Elevation Myocardial Infarction - complications ; ST Elevation Myocardial Infarction - diagnostic imaging ; STEMI ; Surveys and Questionnaires ; Triglycerides ; Ventricle ; Ventricles (cerebral) ; Ventricular Remodeling - physiology
É parte de: Nutrition journal, 2019-05, Vol.18 (1), p.29-29, Article 29
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Descrição: Myocardial infarction (MI) elicits an intense acute inflammatory response that is essential for cardiac repair. However, an excessive inflammatory response also favors myocardial apoptosis, cardiac remodeling, and cardiovascular mortality. Omega-3 polyunsaturated fatty acids (ω-3) bear anti-inflammatory effects, which may mitigate the inflammatory response during MI. This study investigated whether ω-3 intake is associated with attenuation of the MI-related inflammatory response and cardiac remodeling. ST-elevation MI (STEMI) patients (n = 421) underwent clinical, biochemical, nutritional, 3D echocardiogram, Cardiac Magnetic Resonance imaging (CMRi) at 30 days and 3D echocardiogram imaging at six months after the MI. Blood tests were performed at day one (D1) and day five (D5) of hospitalization. Changes in inflammatory markers (ΔD5-D1) were calculated. A validated food frequency questionnaire estimated the nutritional consumption and ω-3 intake in the last 3 months before admission. The intake of ω-3 below the median (< 1.7 g/day) was associated with a short-term increase in hs-C-reactive protein [OR:1.96(1.24-3.10); p = 0.004], Interleukin-2 [OR:2.46(1.20-5.04); p = 0.014], brain-type natriuretic peptide [OR:2.66(1.30-5.44); p = 0.007], left-ventricle end-diastolic volume [OR:5.12(1.11-23.52)]; p = 0.036] and decreases in left-ventricle ejection fraction [OR:2.86(1.47-6.88); p = 0.017] after adjustment for covariates. No differences were observed in the extension of infarcted mass obtained by CMRi. These findings suggest that a reduced daily intake of ω-3 may intensify outcome-determining mechanisms after STEMI, such as acute inflammatory response and late left ventricular remodeling. Clinical Trial Registry number and website: NCT02062554 .
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction

Campos-Staffico, Alessandra M ; Costa, Ana Paula R ; Carvalho, Luiz Sérgio F ; Moura, Filipe A ; Santos, Simone N ; Coelho-Filho, Otavio R ; Nadruz, Jr, Wilson ; Quinaglia E Silva, José C ; Sposito, Andrei C

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.