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Cortical lesions in primary progressive multiple sclerosis : A 2-year longitudinal MR study

CALABRESE, M ; ROCCA, M. A ; GALLO, P ; FILIPPI, M ; ATZORI, M ; MATTISI, I ; BERNARDI, V ; FAVARETTO, A ; BARACHINO, L ; ROMUALDI, C ; RINALDI, L ; PERINI, P

Neurology, 2009-04, Vol.72 (15), p.1330-1336 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Cortical lesions in primary progressive multiple sclerosis : A 2-year longitudinal MR study
Autor: CALABRESE, M ; ROCCA, M. A ; GALLO, P ; FILIPPI, M ; ATZORI, M ; MATTISI, I ; BERNARDI, V ; FAVARETTO, A ; BARACHINO, L ; ROMUALDI, C ; RINALDI, L ; PERINI, P
Assuntos: Adolescent ; Adult ; Biological and medical sciences ; Cerebral Cortex - pathology ; Disease Progression ; Female ; Humans ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Multiple Sclerosis, Chronic Progressive - pathology ; Multivariate Analysis ; Neurology ; Young Adult
É parte de: Neurology, 2009-04, Vol.72 (15), p.1330-1336
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: In primary progressive multiple sclerosis (PPMS), a discrepancy exists between the modest brain white matter (WM) lesion burden and the severity of neurologic disability. Double-inversion recovery (DIR) sequences have improved MRI sensitivity in the detection of cortical lesions (CLs) in patients with relapsing-onset MS. This 2-year longitudinal study was designed to assess the frequency, extent, and rate of formation of CLs in PPMS and their relationship with T2 lesion volume (LV), gray matter (GM) atrophy, and disability. Forty-eight patients with PPMS underwent clinical and magnetic resonance examinations at baseline and after 2 years. The number and volume of CLs, WM T2 LV, and GM fraction (GMf) were assessed at baseline and at follow-up. At baseline, CLs were detected in 81.2% of patients with PPMS. At least one new CL was found in 28 patients during the follow-up. In patients with PPMS, CL and T2 WM LVs increased over the follow-up. At baseline, CL number and volumes were significantly correlated with T2 WM LV, GMf, disease duration, and Expanded Disability Status Scale score, as well as with increasing GM atrophy and disability during the follow-up. A multivariate analysis showed that CL volume at baseline was an independent predictor of percentage GM volume change and disability accumulation during the subsequent 2-year period. Cortical lesions are a frequent finding in primary progressive multiple sclerosis. The extent of such abnormalities is associated with the extent of cortical atrophy and clinical disability, and is able to predict their changes over a medium time period.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Cortical lesions in primary progressive multiple sclerosis : A 2-year longitudinal MR study

CALABRESE, M ; ROCCA, M. A ; GALLO, P ; FILIPPI, M ; ATZORI, M ; MATTISI, I ; BERNARDI, V ; FAVARETTO, A ; BARACHINO, L ; ROMUALDI, C ; RINALDI, L ; PERINI, P

Hagerstown, MD: Lippincott Williams & Wilkins

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