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Strategies to therapeutically modulate cytokine action

Leonard, Warren J ; Lin, Jian-Xin

Nature reviews. Drug discovery, 2023-10, Vol.22 (10), p.827-854 [Periódico revisado por pares]

England: Nature Publishing Group

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  • Título:
    Strategies to therapeutically modulate cytokine action
  • Autor: Leonard, Warren J ; Lin, Jian-Xin
  • Assuntos: Autoimmune diseases ; Autoimmune Diseases - drug therapy ; Cytokines ; Humans ; Immunosuppressive Agents ; Interleukin-2 ; T-Lymphocytes, Regulatory
  • É parte de: Nature reviews. Drug discovery, 2023-10, Vol.22 (10), p.827-854
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, differentiation, growth and survival. Accordingly, the regulation of cytokine activity is extraordinarily important both physiologically and pathologically. Cytokine and/or cytokine receptor engineering is being widely investigated to safely and effectively modulate cytokine activity for therapeutic benefit. IL-2 in particular has been extensively engineered, to create IL-2 variants that differentially exhibit activities on regulatory T cells to potentially treat autoimmune disease versus effector T cells to augment antitumour effects. Additionally, engineering approaches are being applied to many other cytokines such as IL-10, interferons and IL-1 family cytokines, given their immunosuppressive and/or antiviral and anticancer effects. In modulating the actions of cytokines, the strategies used have been broad, including altering affinities of cytokines for their receptors, prolonging cytokine half-lives in vivo and fine-tuning cytokine actions. The field is rapidly expanding, with extensive efforts to create improved therapeutics for a range of diseases.
  • Editor: England: Nature Publishing Group
  • Idioma: Inglês
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