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Cross-Linking Strategies for Electrospun Gelatin Scaffolds

Campiglio, Chiara Emma ; Contessi Negrini, Nicola ; Farè, Silvia ; Draghi, Lorenza

Materials, 2019-08, Vol.12 (15), p.2476 [Periódico revisado por pares]

Switzerland: MDPI AG

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Cross-Linking Strategies for Electrospun Gelatin Scaffolds
Autor: Campiglio, Chiara Emma ; Contessi Negrini, Nicola ; Farè, Silvia ; Draghi, Lorenza
Assuntos: Biocompatibility ; Body temperature ; Collagen ; cross-linking ; Crosslinking ; Electric fields ; Electron beams ; electrospinning ; Free radicals ; Gelatin ; Hydrogels ; Methods ; nanofibers ; natural polymers ; Polymers ; regenerative medicine ; Review ; scaffold ; Sifting ; soft tissues ; Sterilization ; Tissue engineering
É parte de: Materials, 2019-08, Vol.12 (15), p.2476
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors equally contributed.
Descrição: Electrospinning is an exceptional technology to fabricate sub-micrometric fiber scaffolds for regenerative medicine applications and to mimic the morphology and the chemistry of the natural extracellular matrix (ECM). Although most synthetic and natural polymers can be electrospun, gelatin frequently represents a material of choice due to the presence of cell-interactive motifs, its wide availability, low cost, easy processability, and biodegradability. However, cross-linking is required to stabilize the structure of the electrospun matrices and avoid gelatin dissolution at body temperature. Different physical and chemical cross-linking protocols have been described to improve electrospun gelatin stability and to preserve the morphological fibrous arrangement of the electrospun gelatin scaffolds. Here, we review the main current strategies. For each method, the cross-linking mechanism and its efficiency, the influence of electrospinning parameters, and the resulting fiber morphology are considered. The main drawbacks as well as the open challenges are also discussed.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Cross-Linking Strategies for Electrospun Gelatin Scaffolds

Campiglio, Chiara Emma ; Contessi Negrini, Nicola ; Farè, Silvia ; Draghi, Lorenza

Switzerland: MDPI AG

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