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Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells

Han, Kyung-Seok ; Guo, Chong ; Chen, Christopher H. ; Witter, Laurens ; Osorno, Tomas ; Regehr, Wade G.

Neuron (Cambridge, Mass.), 2018-11, Vol.100 (3), p.564-578.e3 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells
  • Autor: Han, Kyung-Seok ; Guo, Chong ; Chen, Christopher H. ; Witter, Laurens ; Osorno, Tomas ; Regehr, Wade G.
  • Assuntos: Action Potentials - physiology ; Animals ; Axons ; Cerebellum ; Cerebellum - chemistry ; Cerebellum - cytology ; Cerebellum - physiology ; Electrodes ; Experiments ; Female ; Information processing ; Male ; Mice ; Mice, Inbred C57BL ; Neocortex ; Neurons ; Neurosciences ; Organ Culture Techniques ; Purkinje cells ; Purkinje Cells - chemistry ; Purkinje Cells - physiology ; Sodium channels ; Synchronization
  • É parte de: Neuron (Cambridge, Mass.), 2018-11, Vol.100 (3), p.564-578.e3
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    K-S.H., C.G., L.W., and W.R. conceived the experiments. C.H.C. and K-S. H. conducted experiments in Figures 1, S1, S2, K-S.H. conducted all other experiments. T.O. aided in the imaging experiments of Figure 8. K-S.H. and C.G. conducted the analysis. K-S.H., C.G., and W.R. wrote the manuscript.
    Author Contributions
  • Descrição: Correlated neuronal activity at various timescales plays an important role in information transfer and processing. We find that in awake-behaving mice, an unexpectedly large fraction of neighboring Purkinje cells (PCs) exhibit sub-millisecond synchrony. Correlated firing usually arises from chemical or electrical synapses, but, surprisingly, neither is required to generate PC synchrony. We therefore assessed ephaptic coupling, a mechanism in which neurons communicate via extracellular electrical signals. In the neocortex, ephaptic signals from many neurons summate to entrain spiking on slow timescales, but extracellular signals from individual cells are thought to be too small to synchronize firing. Here we find that a single PC generates sufficiently large extracellular potentials to open sodium channels in nearby PC axons. Rapid synchronization is made possible because ephaptic signals generated by PCs peak during the rising phase of action potentials. These findings show that ephaptic coupling contributes to the prevalent synchronization of nearby PCs. [Display omitted] •Most nearby PCs fire with sub-millisecond correlations with a zero latency dip•Synchronous PC firing occurs in the absence of chemical and electrical synapses•Extracellular signals activate axonal Na+ channels in nearby PCs to trigger firing•The distance between axon initial segments dictates the extent of synchrony Han et al. find that single cerebellar Purkinje cells generate large extracellular signals during the rising phase of their action potentials that rapidly excite nearby axons to synchronize the firing of neighboring Purkinje cells.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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