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A systematic review of longitudinal outcome studies of first-episode psychosis

MENEZES, N. M. ; ARENOVICH, T. ; ZIPURSKY, R. B.

Psychological medicine, 2006-10, Vol.36 (10), p.1349-1362 [Periódico revisado por pares]

Cambridge, UK: Cambridge University Press

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  • Título:
    A systematic review of longitudinal outcome studies of first-episode psychosis
  • Autor: MENEZES, N. M. ; ARENOVICH, T. ; ZIPURSKY, R. B.
  • Assuntos: Biological and medical sciences ; Clinical outcomes ; Cohort Studies ; Definitions ; Demography ; Drug therapy ; Humans ; Longitudinal Studies ; Medical sciences ; Mental health care ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychosis ; Psychotic Disorders - psychology ; Schizophrenia ; Systematic review
  • É parte de: Psychological medicine, 2006-10, Vol.36 (10), p.1349-1362
  • Notas: ark:/67375/6GQ-46N9CBWK-6
    PII:S0033291706007951
    PMID:16756689
    istex:554451DBF76928F910372FD4E737CBDCAB55BCC7
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    ObjectType-Feature-1
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    ObjectType-Feature-4
    ObjectType-Undefined-1
    ObjectType-Review-2
    ObjectType-Article-3
  • Descrição: Background. Existing outcome literature has had an over-representation of chronic patients and suggested a progressive course and poor outcome for schizophrenia. The current study aimed to recombine data of samples from longitudinal studies of first-episode psychosis (FEP) to describe outcome and its predictors. Method. A literature search (1966–2003) was conducted for prospective studies examining outcome in first-episode non-affective psychosis using the following key words: early, first, incident, episode, admission, contact, psychosis, schizophrenia, psychotic disorders, course, outcome, follow-up, longitudinal, cohort. These were pooled and analyzed using descriptive and regression analyses. Results. Thirty-seven studies met the inclusion criteria, representing 4100 patients with a mean follow-up of 35·1±6·0 months. Studies varied in the categories of outcome used, the most common being ‘good’ (54% of studies) and ‘poor’ (34% of studies), variably defined. In studies reporting these categories, good outcomes were reported in 42·2% (3·5%) and poor outcomes in 27·1% (2·8%) of cases. Predictors associated with better outcome domains were: combination of pharmacotherapy and psychosocial therapy, lack of epidemiologic representativeness of the sample, and a developing country of origin. Use of typical neuroleptics was associated with worse outcome. Stratification analyses suggested that populations with schizophrenia only, and those with prospective design, were associated with worse outcome domains. Conclusions. Outcome from FEP may be more favorable than previously reported, and treatment and methodological variables may be important contributors to outcome. Significant heterogeneity in definitions and methodology limited the comparison and pooling of data. A multi-dimensional, globally used definition of outcome is required for future research.
  • Editor: Cambridge, UK: Cambridge University Press
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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