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Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators

M F Gonçalves, Bruno ; S P Cardoso, David ; U Ferreira, Maria-José

Molecules (Basel, Switzerland), 2020-07, Vol.25 (15), p.3364 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators
Autor: M F Gonçalves, Bruno ; S P Cardoso, David ; U Ferreira, Maria-José
Assuntos: ABC transporter ; ABC transporters ; Aliphatic compounds ; Amino acids ; Antibiotics ; ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry ; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2 - chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism ; ATP-Binding Cassette Transporters - chemistry ; ATP-Binding Cassette Transporters - metabolism ; Binding sites ; Breast cancer ; cancer ; Cancer therapies ; Chemotherapy ; Competition ; Drug Resistance, Multiple - drug effects ; Drugs ; Efflux ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - pharmacology ; Functional groups ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Kinases ; Lymphoma ; Modulators ; Multidrug resistance ; Multidrug Resistance-Associated Proteins - chemistry ; Multidrug Resistance-Associated Proteins - metabolism ; Multidrug resistant organisms ; Natural products ; Neoplasm Proteins - chemistry ; Neoplasm Proteins - metabolism ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Nitrogen ; Nitrogen - chemistry ; nitrogen-containing flavonoid derivatives ; nitrogen-containing terpenoid derivatives ; P-Glycoprotein ; Pharmacokinetics ; Polypeptides ; Protein transport ; Proteins ; Pumps ; Review ; Terpenes - chemistry ; Terpenes - pharmacology ; Tumors
É parte de: Molecules (Basel, Switzerland), 2020-07, Vol.25 (15), p.3364
Descrição: Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance protein 1 (MRP1) is highlighted as a prime factor. Natural product-derived compounds are being addressed as promising ABC transporter modulators to tackle MDR. Flavonoids and terpenoids have been extensively explored in this field as mono or dual modulators of these efflux pumps. Nitrogen-bearing moieties on these scaffolds were proved to influence the modulation of ABC transporters efflux function. This review highlights the potential of semisynthetic nitrogen-containing flavonoid and terpenoid derivatives as candidates for the design of effective MDR reversers. A brief introduction concerning the major role of efflux pumps in multidrug resistance, the potential of natural product-derived compounds in MDR reversal, namely natural flavonoid and terpenoids, and the effect of the introduction of nitrogen-containing groups are provided. The main modifications that have been performed during last few years to generate flavonoid and terpenoid derivatives, bearing nitrogen moieties, such as aliphatic, aromatic and heterocycle amine, amide, and related functional groups, as well as their P-gp, MRP1 and BCRP inhibitory activities are reviewed and discussed.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators

M F Gonçalves, Bruno ; S P Cardoso, David ; U Ferreira, Maria-José

Switzerland: MDPI AG

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