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Influence of Synthesis Conditions on Gadolinium-Substituted Tricalcium Phosphate Ceramics and Its Physicochemical, Biological, and Antibacterial Properties

Fadeeva, Inna V ; Deyneko, Dina V ; Barbaro, Katia ; Davydova, Galina A ; Sadovnikova, Margarita A ; Murzakhanov, Fadis F ; Fomin, Alexander S ; Yankova, Viktoriya G ; Antoniac, Iulian V ; Barinov, Sergey M ; Lazoryak, Bogdan I ; Rau, Julietta V

Nanomaterials (Basel, Switzerland), 2022-03, Vol.12 (5), p.852 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Influence of Synthesis Conditions on Gadolinium-Substituted Tricalcium Phosphate Ceramics and Its Physicochemical, Biological, and Antibacterial Properties
Autor: Fadeeva, Inna V ; Deyneko, Dina V ; Barbaro, Katia ; Davydova, Galina A ; Sadovnikova, Margarita A ; Murzakhanov, Fadis F ; Fomin, Alexander S ; Yankova, Viktoriya G ; Antoniac, Iulian V ; Barinov, Sergey M ; Lazoryak, Bogdan I ; Rau, Julietta V
Assuntos: Admixtures ; Antimicrobial activity ; Apatite ; Aqueous solutions ; Bend strength ; Biological properties ; Calcium ions ; Calcium phosphates ; Cell growth ; Ceramics ; Chemical precipitation ; Contrast agents ; Contrast media ; Dental materials ; Dental pulp ; Dental restorative materials ; E coli ; Electron microscopy ; Electron paramagnetic resonance ; Electron spin resonance ; Gadolinium ; gadolinium doped tricalcium phosphate ; gadolinium tricalcium phosphate ceramics ; gadolinium tricalcium phosphate powder ; gadolinium-substituted tricalcium phosphate ; Grain size ; Heat treatment ; Heat treatments ; Ions ; Magnetic resonance imaging ; Mechanical properties ; Medical imaging ; Methods ; Microscopy ; Nitrates ; Phase composition ; Phosphates ; Pore size ; Salts ; Scanning electron microscopy ; Software ; Spectrum analysis ; Stem cells ; Substitutes ; Surface stability ; Thermal stability ; Thermogravimetric analysis ; Tissue engineering ; Tomography ; Toxicity ; Transmission electron microscopy ; Tricalcium phosphate
É parte de: Nanomaterials (Basel, Switzerland), 2022-03, Vol.12 (5), p.852
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Gadolinium-containing calcium phosphates are promising contrast agents for various bioimaging modalities. Gadolinium-substituted tricalcium phosphate (TCP) powders with 0.51 wt% of gadolinium (0.01Gd-TCP) and 5.06 wt% of (0.1Gd-TCP) were synthesized by two methods: precipitation from aqueous solutions of salts (1) (Gd-TCP-pc) and mechano-chemical activation (2) (Gd-TCP-ma). The phase composition of the product depends on the synthesis method. The product of synthesis (1) was composed of -TCP (main phase, 96%), apatite/chlorapatite (2%), and calcium pyrophosphate (2%), after heat treatment at 900 °C. The product of synthesis (2) was represented by -TCP (main phase, 73%), apatite/chlorapatite (20%), and calcium pyrophosphate (7%), after heat treatment at 900 °C. The substitution of Ca ions by Gd in both -TCP (main phase) and apatite (admixture) phases was proved by the electron paramagnetic resonance technique. The thermal stability and specific surface area of the Gd-TCP powders synthesized by two methods were significantly different. The method of synthesis also influenced the size and morphology of the prepared Gd-TCP powders. In the case of synthesis route (1), powders with particle sizes of tens of nanometers were obtained, while in the case of synthesis (2), the particle size was hundreds of nanometers, as revealed by transmission electron microscopy. The Gd-TCP ceramics microstructure investigated by scanning electron microscopy was different depending on the synthesis route. In the case of (1), ceramics with grains of 1-50 μm, pore sizes of 1-10 µm, and a bending strength of about 30 MPa were obtained; in the case of (2), the ceramics grain size was 0.4-1.4 μm, the pore size was 2 µm, and a bending strength of about 39 MPa was prepared. The antimicrobial activity of powders was tested for four bacteria ( , , , and ) and one fungus ( ), and there was roughly 30% of inhibition of the micro-organism's growth. The metabolic activity of the NCTC L929 cell and viability of the human dental pulp stem cell study demonstrated the absence of toxic effects for all the prepared ceramic materials doped with Gd ions, with no difference for the synthesis route.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Influence of Synthesis Conditions on Gadolinium-Substituted Tricalcium Phosphate Ceramics and Its Physicochemical, Biological, and Antibacterial Properties

Fadeeva, Inna V ; Deyneko, Dina V ; Barbaro, Katia ; Davydova, Galina A ; Sadovnikova, Margarita A ; Murzakhanov, Fadis F ; Fomin, Alexander S ; Yankova, Viktoriya G ; Antoniac, Iulian V ; Barinov, Sergey M ; Lazoryak, Bogdan I ; Rau, Julietta V

Switzerland: MDPI AG

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