Idioma:

Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis

Ramanathan, Sudarshini ; Prelog, Kristina ; Barnes, Elizabeth H ; Tantsis, Esther M ; Reddel, Stephen W ; Henderson, Andrew PD ; Vucic, Steve ; Gorman, Mark P ; Benson, Leslie A ; Alper, Gulay ; Riney, Catherine J ; Barnett, Michael ; Parratt, John DE ; Hardy, Todd A ; Leventer, Richard J ; Merheb, Vera ; Nosadini, Margherita ; Fung, Victor SC ; Brilot, Fabienne ; Dale, Russell C

Multiple sclerosis, 2016-04, Vol.22 (4), p.470-482 [Periódico revisado por pares]

London, England: SAGE Publications

Texto completo disponível

Citações Citado por

Enviar para

Título:
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis
Autor: Ramanathan, Sudarshini ; Prelog, Kristina ; Barnes, Elizabeth H ; Tantsis, Esther M ; Reddel, Stephen W ; Henderson, Andrew PD ; Vucic, Steve ; Gorman, Mark P ; Benson, Leslie A ; Alper, Gulay ; Riney, Catherine J ; Barnett, Michael ; Parratt, John DE ; Hardy, Todd A ; Leventer, Richard J ; Merheb, Vera ; Nosadini, Margherita ; Fung, Victor SC ; Brilot, Fabienne ; Dale, Russell C
Assuntos: Adolescent ; Adult ; Age of Onset ; Antibodies ; Aquaporin 4 ; Aquaporin 4 - immunology ; Aquaporins ; Autoantibodies - blood ; Biomarkers - blood ; Child ; Child, Preschool ; Demyelination ; Diagnosis, Differential ; Female ; Glycoproteins ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - blood ; Multiple Sclerosis - diagnostic imaging ; Multiple Sclerosis - immunology ; Myelin ; Myelin-Oligodendrocyte Glycoprotein - immunology ; Neuritis ; Neuroimaging ; Oligodendrocyte-myelin glycoprotein ; Optic nerve ; Optic neuritis ; Optic Neuritis - blood ; Optic Neuritis - diagnostic imaging ; Optic Neuritis - immunology ; Optic tract ; Optic Tract - diagnostic imaging ; Predictive Value of Tests ; Retrospective Studies ; Young Adult
É parte de: Multiple sclerosis, 2016-04, Vol.22 (4), p.470-482
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Background: Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes. Objective: We aimed to define radiological features of first-episode demyelinating ON. Methods: We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON (n=7). Results: Bilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal involvement was more common in AQP4-ON (5% vs. 64% vs. 15%), and bilateral optic tract involvement was more common in AQP4-ON (0% vs. 45% vs. 0%). Retrobulbar involvement was more common in MOG-ON, whereas intracranial involvement was more common in AQP4-ON. MOG-ON and AQP4-ON had longer lesion lengths than MS-ON. The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. AQP4-ON more frequently had severe and sustained visual impairment. Conclusion: MOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway.
Editor: London, England: SAGE Publications
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis

London, England: SAGE Publications

Buscando em bases de dados remotas. Favor aguardar.